Heat-Killed Enterococcus faecalis Prevents Adipogenesis and High Fat Diet-Induced Obesity by Inhibition of Lipid Accumulation through Inhibiting C/EBP-α and PPAR-γ in the Insulin Signaling Pathway

• Published in: Nutrients Vol. 14; no. 6; p. 1308
• Main Authors: Lee, Jin-Ho, Woo, Keun-Jung, Kim, Min-Ah, Hong, Joonpyo, Kim, Jihee, Kim, Sun-Hong, Han, Kwon-Il, Iwasa, Masahiro, Kim, Tack-Joong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.03.2022; MDPI
• Subjects: Adipocytes; Adipogenesis; Animals; Body fat; Cell cycle; cholesterol; Diet; Diet, High-Fat - adverse effects; Enterococcus faecalis; High density lipoprotein; high fat diet; Hot Temperature; inflammation; insulin; Insulin - pharmacology; insulin receptors; Insulin resistance; Lipids; Microscopy; neoplasm progression; Obesity; Obesity - etiology; Obesity - metabolism; Obesity - prevention & control; oral administration; pandemic; phosphorylation; PPAR gamma - metabolism; Proteins; Rats; sedentary lifestyle; Signal Transduction; Stains & staining; triacylglycerols; Triglycerides - pharmacology; Western blotting; United States > US; Enterococcus faecalis; adipogenesis; 3T3-L1; high fat diet; obesity; parabiotic

Increasing consumption of food with high caloric density and a sedentary lifestyle have influenced the increasing obesity prevalence worldwide. The recent pandemic has contributed to this problem. Obesity refers to a state in which lipid accumulates excessively in adipocytes and adipose tissues. Dri...