A Polysaccharide Isolated from Dictyophora indusiata Promotes Recovery from Antibiotic-Driven Intestinal Dysbiosis and Improves Gut Epithelial Barrier Function in a Mouse Model

• Published in: Nutrients Vol. 10; no. 8; p. 1003
• Main Authors: Kanwal, Sadia, Joseph, Thomson Patrick, Owusu, Lawrence, Xiaomeng, Ren, Meiqi, Li, Yi, Xin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.07.2018; MDPI
• Subjects: absorption barrier; animal models; Antibiotics; bacteria; Bacteroides; blood serum; clindamycin; colon; Cytokines; Dictyophora; dysbiosis; endotoxemia; endotoxins; Enterococcus; epithelium; flora; histology; inflammation; interleukin-1beta; interleukin-6; intestinal microorganisms; Lactobacillaceae; lipopolysaccharides; metronidazole; mice; microbial communities; Microbiota; mushrooms; occludins; oral administration; protective effect; Proteobacteria; tight junctions; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; polysaccharide; Dictyophora indusiata; immunology; gut microbiota; restoration; broad-spectrum antibiotics; dysbiosis

Despite the tremendous biological activity of polysaccharides from the mushroom Dictyophora indusiata, its role in the restoration of gut microbiota has not yet been explored. The present study aimed to investigate whether D. indusiata polysaccharide (DIP) could modulate the recovery of gut microbio...