Cell-Based Measures of Viral Persistence Are Associated With Immune Activation and Programmed Cell Death Protein 1 (PD-1)—Expressing CD4+T cells

• Published in: The Journal of infectious diseases Vol. 208; no. 1; pp. 50 - 56
• Main Authors: Hatano, Hiroyu, Jain, Vivek, Hunt, Peter W., Lee, Tzong-Hae, Sinclair, Elizabeth, Do, Tri D., Hoh, Rebecca, Martin, Jeffrey N., McCune, Joseph M., Hecht, Frederick, Busch, Michael P., Deeks, Steven G.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2013
• Subjects: Adult; AIDS; Antiretroviral Therapy, Highly Active; Antiretrovirals; Biological and medical sciences; Blood plasma; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - immunology; DNA; DNA, Viral - drug effects; Female; Fundamental and applied biological sciences. Psychology; Highly active antiretroviral therapy; HIV; HIV - drug effects; HIV 1; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV/AIDS; Humans; Immunity, Cellular - drug effects; Infectious diseases; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Major and Brief Reports; Male; Medical sciences; Microbiology; Middle Aged; Programmed Cell Death 1 Receptor - blood; Proviruses - drug effects; RNA; RNA, Viral - blood; T lymphocytes; Virology; Infection; CD4 T lymphocyte; Protein; Apoptosis; D-dimer; 2-LTR circles; HIV; ongoing viral replication; raltegravir intensification

Background. Studies aimed at defining the association between host immune responses and human immunodeficiency virus (HIV) persistence during therapy are necessary to develop new strategies for cure. Methods. We performed a comprehensive assessment of ultrasensitive plasma HIV RNA levels, cell-assoc...