Diesel exhaust particles exposure exacerbates pro-thrombogenic plasma features ex-vivo after cerebral ischemia and accelerates tPA-induced clot-lysis in hypertensive subjects

• Published in: Journal of cerebral blood flow and metabolism Vol. 44; no. 5; pp. 772 - 786
• Main Authors: Arrúe, Mercedes, Penalba, Anna, Rodriguez-Bodero, Ane, Elicegui, Amaia, de Homdedeu, Miquel, Cruz, María-Jesús, Simats, Alba, Rodriguez, Susana, Buxó, Xavier, Garcia-Rodriguez, Nicolás, Pizarro, Jesús, Turner, Michelle C, Delgado, Pilar, Rosell, Anna
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2024
• Subjects: Aged; Animals; Brain Ischemia - blood; Brain Ischemia - etiology; Female; Fibrinolysis - drug effects; Humans; Hypertension; Ischemic Stroke - blood; Ischemic Stroke - etiology; Male; Mice; Mice, Inbred C57BL; Middle Aged; Original; Particulate Matter - toxicity; Thrombosis - etiology; Tissue Plasminogen Activator - blood; Vehicle Emissions - toxicity; clot; Stroke; air pollution; diesel exhaust particles; thrombogenicity

The combustion of fossil fuels, mainly by diesel engines, generates Diesel Exhaust Particles (DEP) which are the main source of Particulate Matter (PM), a major air pollutant in urban areas. These particles are a risk factor for stroke with 5.6% of cases attributed to PM exposure. Our aim was to eva...