Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence

• Published in: Frontiers in oncology Vol. 11; p. 742037
• Main Authors: Yu, Jinliang, Sheng, Zhiyuan, Wu, Shuang, Gao, Yushuai, Yan, Zhaoyue, Bu, Chaojie, Gu, Jianjun, Bu, Yage, Deng, Kaiyuan, Xu, Sensen, Chen, Zhongcan, Zhang, Qianqian, Zemmar, Ajmal, Hernesniemi, Juha, Wang, Meiyun, Liu, Gang, Li, Tianxiao, Bu, Xingyao
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 11.10.2021
• Subjects: circulating tumor DNA; glioma progression; Oncology; precision medicine; spatiotemporal heterogeneity; tumor in-situ fluid

The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (T...