Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence

The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (T...

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Published inFrontiers in oncology Vol. 11; p. 742037
Main Authors Yu, Jinliang, Sheng, Zhiyuan, Wu, Shuang, Gao, Yushuai, Yan, Zhaoyue, Bu, Chaojie, Gu, Jianjun, Bu, Yage, Deng, Kaiyuan, Xu, Sensen, Chen, Zhongcan, Zhang, Qianqian, Zemmar, Ajmal, Hernesniemi, Juha, Wang, Meiyun, Liu, Gang, Li, Tianxiao, Bu, Xingyao
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 11.10.2021
Subjects
circulating tumor DNA
glioma progression
Oncology
precision medicine
spatiotemporal heterogeneity
tumor in-situ fluid
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Abstract The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (TISF-DNA) can detect genomic changes in recurrent tumors and facilitate recurrence risk analysis, providing valuable information for diagnosis and prognosis. The tumor DNA in TISF is more representative and sensitive than that in cerebrospinal fluid. It reveals the mutational landscape of minimal residual disease after glioma surgery and the risk of early recurrence, contributing to the clinical management and clinical research of glioma patients.
AbstractList The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (TISF-DNA) can detect genomic changes in recurrent tumors and facilitate recurrence risk analysis, providing valuable information for diagnosis and prognosis. The tumor DNA in TISF is more representative and sensitive than that in cerebrospinal fluid. It reveals the mutational landscape of minimal residual disease after glioma surgery and the risk of early recurrence, contributing to the clinical management and clinical research of glioma patients.
The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (TISF-DNA) can detect genomic changes in recurrent tumors and facilitate recurrence risk analysis, providing valuable information for diagnosis and prognosis. The tumor DNA in TISF is more representative and sensitive than that in cerebrospinal fluid. It reveals the mutational landscape of minimal residual disease after glioma surgery and the risk of early recurrence, contributing to the clinical management and clinical research of glioma patients.
Author Liu, Gang
Wu, Shuang
Bu, Yage
Yan, Zhaoyue
Gao, Yushuai
Wang, Meiyun
Li, Tianxiao
Bu, Xingyao
Yu, Jinliang
Zemmar, Ajmal
Chen, Zhongcan
Xu, Sensen
Zhang, Qianqian
Hernesniemi, Juha
Deng, Kaiyuan
Sheng, Zhiyuan
Gu, Jianjun
Bu, Chaojie
AuthorAffiliation 5 Department of Medical Imaging, Henan Provincial People’s Hospital, The People’s Hospital of Zhengzhou University , Zhengzhou , China
2 Department of Neurosurgery, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital , Zhengzhou , China
7 Department of Center for Clinical Single Cell Biomedicine, Clinical Research Center, Department of Oncology, Henan Provincial People’s Hospital, The People’s Hospital of Zhengzhou University , Zhengzhou , China
1 Department of Neurosurgery, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital , Zhengzhou , China
4 Juha International Center for Neurosurgery, Henan Provincial People’s Hospital , Zhengzhou , China
6 Henan Provincial Key Laboratory for Imaging Diagnosis and Research of Neurological Diseases, Henan Provincial People’s Hospital, The People’s Hospital of Zhengzhou University , Zhengzhou , China
3 Juha International Central Laboratory of Neurosurgery, Henan Provincia
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These authors share senior authorship
Edited by: Khan Iftekharuddin, Old Dominion University, United States
These authors have contributed equally to this work
Reviewed by: Giselle Lopez, Duke University, United States; Ayca Erşen Danyeli, Associate Professor, İstanbul, Turkey
This article was submitted to Neuro-Oncology and Neurosurgical Oncology, a section of the journal Frontiers in Oncology
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glioma progression
Oncology
precision medicine
spatiotemporal heterogeneity
tumor in-situ fluid
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Title Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence
URI https://search.proquest.com/docview/2590109711
https://pubmed.ncbi.nlm.nih.gov/PMC8547270
https://doaj.org/article/e15e187d8d9247cc898cae06f77afda2
Volume 11
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