Identification and Validation of METTL3-Related Molecules for Predicting Prognosis and Efficacy of Immunotherapy in Gastric Cancer Based on m6A Methylome and Transcriptome Sequencing Analysis

• Published in: Frontiers in oncology Vol. 12; p. 935239
• Main Authors: Chen, Shuran, Su, Xu, Wang, Jing, Zheng, Ni, Tang, Yuan, Peng, Guisen, Dong, Rui, Lu, Fei, Liu, Mulin, Zhao, Yunli, Wu, Huazhang
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 29.07.2022
• Subjects: gastric cancer; immune checkpoint; immune microenvironment; m6A modification; METTL3; Oncology

Abnormal N6-methyladenosine (m6A) modification levels caused by METTL3 have been identified to be a critical regulator in human cancers, and its roles in the immune microenvironment and the relationship between targeted therapy and immunotherapy sensitivity in gastric cancer (GC) remain poorly under...