Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals

• Published in: Nutrients Vol. 11; no. 10; p. 2470
• Main Authors: Chowdhury, Abeed H., Cámara, Miguel, Verma, Chandan, Eremin, Oleg, Kulkarni, Anil D., Lobo, Dileep N.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.10.2019; MDPI
• Subjects: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents - administration & dosage; Antibiotics; Antigens; azithromycin; Azithromycin - administration & dosage; Bacteria; Bacterial infections; Bifidobacterium longum; Bifidobacterium longum - growth & development; Bifidobacterium longum - immunology; Cytokines; Cytokines - immunology; Cytokines - metabolism; Dendritic cells; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - microbiology; Diarrhea; Double-Blind Method; England; Healthy Volunteers; Host-Pathogen Interactions; Human subjects; Humans; Immune system; Inflammatory bowel disease; interferon-gamma; interleukin-4; Lentinula edodes; Life sciences; Lymphocytes; Male; males; Metabolic syndrome; Middle Aged; mycelium; oral administration; Pathogens; Phenotype; Pilot Projects; placebos; Prebiotics; Probiotics; Probiotics - administration & dosage; secretion; Shiitake Mushrooms - growth & development; Shiitake Mushrooms - immunology; T-lymphocytes; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T-Lymphocytes, Regulatory - microbiology; volunteers; Young Adult; England; United Kingdom > UK; United States > US; Japan; dendritic cells; AHCC; Bifidobacterium longum; prebiotics; immunity; synbiotics; antibiotics; probiotics

The probiotic Bifidus BB536 (BB536), which contains Bifidobacterium longum, has been shown to have enhanced probiotic effects when given together with a standardized extract of cultured Lentinula edodes mycelia (AHCC®, Amino Up Co. Ltd., Sapporo, Japan). BB536 and AHCC® may modulate T cell and dendr...