Thyroid Imaging Reporting and Data System for Detecting Diffuse Thyroid Disease on Ultrasonography: A Single-Center Study
Objective: This study aimed to compare the ultrasonography (US) features of diffuse thyroid disease (DTD) and normal thyroid parenchyma (NTP), and to propose a structured imaging reporting system for detecting DTD. Methods: This retrospective study assessed the findings for 270 consecutive patients...
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Published in | Frontiers in endocrinology (Lausanne) Vol. 10; p. 776 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Frontiers Media S.A
08.11.2019
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Abstract | Objective:
This study aimed to compare the ultrasonography (US) features of diffuse thyroid disease (DTD) and normal thyroid parenchyma (NTP), and to propose a structured imaging reporting system for detecting DTD.
Methods:
This retrospective study assessed the findings for 270 consecutive patients who underwent thyroid US before thyroid surgery. The following US data were analyzed: DTD-specific features, parenchymal echotexture and echogenicity, anteroposterior diameter, glandular margin, and parenchymal vascularity. Univariate and multivariate analyses with generalized estimating equations were performed to investigate the relationship between US features and DTD. The fitted probability of DTD was analyzed by using a regression equation.
Results:
Of the 270 patients, there were NTP (
n
= 193), Hashimoto thyroiditis (
n
= 24), non-Hashimoto lymphocytic thyroiditis (
n
= 51), Graves' disease (
n
= 1), and diffuse hyperplasia (
n
= 1). The following US features were significantly associated with DTD: decreased or increased parenchymal echogenicity, coarse parenchymal echotexture, increased anteroposterior diameter, lobulated glandular margin, and increased parenchymal vascularity. Of these, coarse parenchymal echotexture was the most significant independent predictor of DTD. The numbers of abnormal US features were positively correlated with the fitted probability and risk of DTD. The diagnostic indices were highest when the chosen cut-off criterion was category III with the largest Az value (0.867, 95% confidence interval: 0.820–0.905), yielding a sensitivity of 68.8%, specificity of 92.2%, positive predictive value of 77.9%, negative predictive value of 88.1%, and accuracy of 85.6% (
p
< 0.001).
Conclusions:
Our sonographic reporting and data system may be useful for detecting DTD. |
---|---|
AbstractList | Objective: This study aimed to compare the ultrasonography (US) features of diffuse thyroid disease (DTD) and normal thyroid parenchyma (NTP), and to propose a structured imaging reporting system for detecting DTD.Methods: This retrospective study assessed the findings for 270 consecutive patients who underwent thyroid US before thyroid surgery. The following US data were analyzed: DTD-specific features, parenchymal echotexture and echogenicity, anteroposterior diameter, glandular margin, and parenchymal vascularity. Univariate and multivariate analyses with generalized estimating equations were performed to investigate the relationship between US features and DTD. The fitted probability of DTD was analyzed by using a regression equation.Results: Of the 270 patients, there were NTP (n = 193), Hashimoto thyroiditis (n = 24), non-Hashimoto lymphocytic thyroiditis (n = 51), Graves' disease (n = 1), and diffuse hyperplasia (n = 1). The following US features were significantly associated with DTD: decreased or increased parenchymal echogenicity, coarse parenchymal echotexture, increased anteroposterior diameter, lobulated glandular margin, and increased parenchymal vascularity. Of these, coarse parenchymal echotexture was the most significant independent predictor of DTD. The numbers of abnormal US features were positively correlated with the fitted probability and risk of DTD. The diagnostic indices were highest when the chosen cut-off criterion was category III with the largest Az value (0.867, 95% confidence interval: 0.820–0.905), yielding a sensitivity of 68.8%, specificity of 92.2%, positive predictive value of 77.9%, negative predictive value of 88.1%, and accuracy of 85.6% (p < 0.001).Conclusions: Our sonographic reporting and data system may be useful for detecting DTD. Objective: This study aimed to compare the ultrasonography (US) features of diffuse thyroid disease (DTD) and normal thyroid parenchyma (NTP), and to propose a structured imaging reporting system for detecting DTD. Methods: This retrospective study assessed the findings for 270 consecutive patients who underwent thyroid US before thyroid surgery. The following US data were analyzed: DTD-specific features, parenchymal echotexture and echogenicity, anteroposterior diameter, glandular margin, and parenchymal vascularity. Univariate and multivariate analyses with generalized estimating equations were performed to investigate the relationship between US features and DTD. The fitted probability of DTD was analyzed by using a regression equation. Results: Of the 270 patients, there were NTP ( n = 193), Hashimoto thyroiditis ( n = 24), non-Hashimoto lymphocytic thyroiditis ( n = 51), Graves' disease ( n = 1), and diffuse hyperplasia ( n = 1). The following US features were significantly associated with DTD: decreased or increased parenchymal echogenicity, coarse parenchymal echotexture, increased anteroposterior diameter, lobulated glandular margin, and increased parenchymal vascularity. Of these, coarse parenchymal echotexture was the most significant independent predictor of DTD. The numbers of abnormal US features were positively correlated with the fitted probability and risk of DTD. The diagnostic indices were highest when the chosen cut-off criterion was category III with the largest Az value (0.867, 95% confidence interval: 0.820–0.905), yielding a sensitivity of 68.8%, specificity of 92.2%, positive predictive value of 77.9%, negative predictive value of 88.1%, and accuracy of 85.6% ( p < 0.001). Conclusions: Our sonographic reporting and data system may be useful for detecting DTD. |
Author | Choo, Hye Jung Shin, Gi Won Kim, Dong Wook Ahn, Ki Jung Baek, Hye Jin Moon, Sung Ho Jung, Soo Jin Ryu, Kyeong Hwa Ha, Tae Kwun Lee, Yoo Jin Park, Ha Kyoung Park, Ji Sun Kim, Do Hun Park, Jin Young |
AuthorAffiliation | 3 Department of General Surgery, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea 6 Department of Nuclear Medicine, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea 8 Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea 4 Department of Otorhinolaryngology-Head and Neck Surgery, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea 7 Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea 5 Department of Pathology, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea 1 Department of Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine , Changwon , South Korea 2 Department of Radiology, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea |
AuthorAffiliation_xml | – name: 5 Department of Pathology, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea – name: 7 Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea – name: 2 Department of Radiology, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea – name: 1 Department of Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine , Changwon , South Korea – name: 6 Department of Nuclear Medicine, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea – name: 8 Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea – name: 4 Department of Otorhinolaryngology-Head and Neck Surgery, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea – name: 3 Department of General Surgery, Busan Paik Hospital, Inje University College of Medicine , Busan , South Korea |
Author_xml | – sequence: 1 givenname: Hye Jin surname: Baek fullname: Baek, Hye Jin – sequence: 2 givenname: Dong Wook surname: Kim fullname: Kim, Dong Wook – sequence: 3 givenname: Kyeong Hwa surname: Ryu fullname: Ryu, Kyeong Hwa – sequence: 4 givenname: Gi Won surname: Shin fullname: Shin, Gi Won – sequence: 5 givenname: Jin Young surname: Park fullname: Park, Jin Young – sequence: 6 givenname: Yoo Jin surname: Lee fullname: Lee, Yoo Jin – sequence: 7 givenname: Hye Jung surname: Choo fullname: Choo, Hye Jung – sequence: 8 givenname: Ha Kyoung surname: Park fullname: Park, Ha Kyoung – sequence: 9 givenname: Tae Kwun surname: Ha fullname: Ha, Tae Kwun – sequence: 10 givenname: Do Hun surname: Kim fullname: Kim, Do Hun – sequence: 11 givenname: Soo Jin surname: Jung fullname: Jung, Soo Jin – sequence: 12 givenname: Ji Sun surname: Park fullname: Park, Ji Sun – sequence: 13 givenname: Sung Ho surname: Moon fullname: Moon, Sung Ho – sequence: 14 givenname: Ki Jung surname: Ahn fullname: Ahn, Ki Jung |
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Copyright | Copyright © 2019 Baek, Kim, Ryu, Shin, Park, Lee, Choo, Park, Ha, Kim, Jung, Park, Moon and Ahn. 2019 Baek, Kim, Ryu, Shin, Park, Lee, Choo, Park, Ha, Kim, Jung, Park, Moon and Ahn |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology Reviewed by: Trevor Edmund Angell, University of Southern California, United States; Cheng Han, Albert Einstein College of Medicine, United States Edited by: Terry Francis Davies, Icahn School of Medicine at Mount Sinai, United States |
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Snippet | Objective:
This study aimed to compare the ultrasonography (US) features of diffuse thyroid disease (DTD) and normal thyroid parenchyma (NTP), and to propose a... Objective: This study aimed to compare the ultrasonography (US) features of diffuse thyroid disease (DTD) and normal thyroid parenchyma (NTP), and to propose a... |
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SubjectTerms | autoimmune thyroiditis diffuse thyroid disease Endocrinology thyroid TIRADS ultrasonography |
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Title | Thyroid Imaging Reporting and Data System for Detecting Diffuse Thyroid Disease on Ultrasonography: A Single-Center Study |
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