Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models

• Published in: International journal of molecular sciences Vol. 26; no. 14; p. 7026
• Main Authors: Kehinde, Samuel Abiodun, Lin, Wai Phyo, Lay, Bo Bo, Phyo, Khin Yadanar, San, Myat Mon, Pattanayaiying, Rinrada, Chusri, Sasitorn
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.07.2025; MDPI
• Subjects: Alzheimer's disease; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Arsenic; Biomarkers; Cognition - drug effects; Cognitive ability; Curcumin - pharmacology; Curcumin - therapeutic use; Dementia; Dementia - drug therapy; Dementia - metabolism; Disease; Disease Models, Animal; Humans; Inflammation; Medical research; Medical Subject Headings-MeSH; Medicine, Experimental; Memory; Meta-analysis; Nervous system diseases; Neurodegeneration; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurotoxicity; Oxidative stress; Oxidative Stress - drug effects; Pathology; Review; Superoxide; Systematic review; Tomography; cognitive function; animal models; antioxidant; curcuma longa; neuroinflammation; dementia; oxidative stress; curcumin
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms26147026

Dementia is marked by progressive cognitive decline linked to oxidative stress, neuroinflammation, and synaptic dysfunction. Curcumin, a natural compound from Curcuma longa, has shown promising neuroprotective effects. This systematic review analyzed 29 preclinical studies using rodent models of dem...