Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial

• Published in: Pharmaceutical research Vol. 36; no. 7; pp. 93 - 12
• Main Authors: Lavezzi, Silvia Maria, de Jong, Jan, Neyens, Martine, Cramer, Paula, Demirkan, Fatih, Fraser, Graeme, Bartlett, Nancy, Dilhuydy, Marie-Sarah, Loscertales, Javier, Avigdor, Abraham, Rule, Simon, Samoilova, Olga, Goy, Andre, Ganguly, Siddhartha, Salman, Mariya, Howes, Angela, Mahler, Michelle, De Nicolao, Giuseppe, Poggesi, Italo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2019; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Antimitotic agents; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; B cells; Bendamustine Hydrochloride - adverse effects; Bendamustine Hydrochloride - pharmacokinetics; Bendamustine Hydrochloride - therapeutic use; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Chronic lymphocytic leukemia; Female; Humans; Immunotherapy; Inhibitor drugs; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Lymphatic leukemia; Lymphoma; Male; Medical colleges; Medical Law; Middle Aged; Models, Biological; Monoclonal antibodies; Non-Hodgkin's lymphomas; Pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Pyrazoles - metabolism; Pyrimidines - metabolism; Research Paper; Rituximab; Rituximab - pharmacokinetics; Targeted cancer therapy; Treatment Outcome; ibrutinib; pharmacokinetics; modeling; rituximab; bendamustine

Introduction In the HELIOS trial, bendamustine/rituximab (BR) plus ibrutinib (BR-I) improved disease outcomes versus BR plus placebo in previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma. Here, we describe the pharmacokinetic (PK) observations, along with modeling to further...