Sequencing Analysis of Plasma Epstein-Barr Virus DNA Reveals Nasopharyngeal Carcinoma-Associated Single Nucleotide Variant Profiles

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 66; no. 4; pp. 598 - 605
• Main Authors: Lam, W K Jacky, Ji, Lu, Tse, O Y Olivia, Cheng, Suk Hang, Jiang, Peiyong, Lee, P H Patrick, Lin, S Vivien, Hui, Edwin P, Ma, Brigette B Y, Chan, Anthony T C, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2020; American Association for Clinical Chemistry, Inc
• Subjects: Analysis; Cancer; Carcinoma; Deoxyribonucleic acid; DNA; DNA sequencing; DNA viruses; Epstein-Barr virus; Genetic aspects; Genetic research; Genomes; Genomics; Health aspects; Health risks; Low concentrations; Nasopharyngeal carcinoma; Nucleotide sequencing; Nucleotides; Plasma; Sequence analysis; Throat cancer; Training; Viruses; China; nasopharyngeal carcinoma; screening; Epstein-Barr virus; risk prediction

Abstract Background Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. Plasma EBV DNA is a validated screening tool for NPC. In screening, there are some individuals who do not have NPC but carry EBV DNA in plasma. Currently it is not known from screening...