Polyphenols in Parkinson’s Disease: A Systematic Review of In Vivo Studies

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols hav...

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Published inNutrients Vol. 10; no. 5; p. 642
Main Authors Kujawska, Małgorzata, Jodynis-Liebert, Jadwiga
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.05.2018
MDPI
Subjects
animal models
Animals
Antiparkinson Agents - adverse effects
Antiparkinson Agents - metabolism
Antiparkinson Agents - therapeutic use
Behavior, Animal - drug effects
blood-brain barrier
brain
Brain - drug effects
Brain - metabolism
Brain - physiopathology
cognition
Disease Models, Animal
dopamine
histopathology
Humans
immunohistochemistry
in vivo studies
iron
metabolites
Mice
Motor Activity - drug effects
neurons
Neuroprotective Agents - adverse effects
Neuroprotective Agents - metabolism
Neuroprotective Agents - therapeutic use
neuroprotective effect
oxidative stress
Parkinson disease
Parkinson Disease - diagnosis
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Parkinson Disease - psychology
Parkinson's disease
Permeability
Polyphenols
Polyphenols - adverse effects
Polyphenols - metabolism
Polyphenols - therapeutic use
Rats
Review
signal transduction
Systematic review
therapeutics
Treatment Outcome
rotenone
behavioral tests
urolithins
Online AccessGet full text

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Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols have gained great interest as potential therapeutic agents. Herein, we have attempted to summarize results obtained in different animal models demonstrating their neuroprotective effects. The in vivo findings presented below are supported by human subject data and reports regarding the ability of polyphenols to cross the blood-brain barrier. The beneficial effects of polyphenols are demonstrated by the results of behavioral examinations, mainly related to motor and cognitive capabilities, histopathological and immunohistochemical examination concerning the protection of dopaminergic neurons, analyses of dopamine and the concentration of its metabolites, as well as mechanistic studies regarding the modulation of oxidative stress, neuroinflammation, cellular iron management, proteinopathy, and additionally the regulation of signaling pathways. Importantly, data about brain distribution of the metabolic derivatives of the reviewed polyphenols are crucial for the justification of their nutritional intake in neuroprotective intervention, as well as for the identification of potential targets for a novel therapeutic approach to Parkinson’s disease.
AbstractList Parkinson’s disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols have gained great interest as potential therapeutic agents. Herein, we have attempted to summarize results obtained in different animal models demonstrating their neuroprotective effects. The in vivo findings presented below are supported by human subject data and reports regarding the ability of polyphenols to cross the blood-brain barrier. The beneficial effects of polyphenols are demonstrated by the results of behavioral examinations, mainly related to motor and cognitive capabilities, histopathological and immunohistochemical examination concerning the protection of dopaminergic neurons, analyses of dopamine and the concentration of its metabolites, as well as mechanistic studies regarding the modulation of oxidative stress, neuroinflammation, cellular iron management, proteinopathy, and additionally the regulation of signaling pathways. Importantly, data about brain distribution of the metabolic derivatives of the reviewed polyphenols are crucial for the justification of their nutritional intake in neuroprotective intervention, as well as for the identification of potential targets for a novel therapeutic approach to Parkinson’s disease.
Parkinson's disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols have gained great interest as potential therapeutic agents. Herein, we have attempted to summarize results obtained in different animal models demonstrating their neuroprotective effects. The in vivo findings presented below are supported by human subject data and reports regarding the ability of polyphenols to cross the blood-brain barrier. The beneficial effects of polyphenols are demonstrated by the results of behavioral examinations, mainly related to motor and cognitive capabilities, histopathological and immunohistochemical examination concerning the protection of dopaminergic neurons, analyses of dopamine and the concentration of its metabolites, as well as mechanistic studies regarding the modulation of oxidative stress, neuroinflammation, cellular iron management, proteinopathy, and additionally the regulation of signaling pathways. Importantly, data about brain distribution of the metabolic derivatives of the reviewed polyphenols are crucial for the justification of their nutritional intake in neuroprotective intervention, as well as for the identification of potential targets for a novel therapeutic approach to Parkinson's disease.Parkinson's disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols have gained great interest as potential therapeutic agents. Herein, we have attempted to summarize results obtained in different animal models demonstrating their neuroprotective effects. The in vivo findings presented below are supported by human subject data and reports regarding the ability of polyphenols to cross the blood-brain barrier. The beneficial effects of polyphenols are demonstrated by the results of behavioral examinations, mainly related to motor and cognitive capabilities, histopathological and immunohistochemical examination concerning the protection of dopaminergic neurons, analyses of dopamine and the concentration of its metabolites, as well as mechanistic studies regarding the modulation of oxidative stress, neuroinflammation, cellular iron management, proteinopathy, and additionally the regulation of signaling pathways. Importantly, data about brain distribution of the metabolic derivatives of the reviewed polyphenols are crucial for the justification of their nutritional intake in neuroprotective intervention, as well as for the identification of potential targets for a novel therapeutic approach to Parkinson's disease.
Author Kujawska, Małgorzata
Jodynis-Liebert, Jadwiga
AuthorAffiliation Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznań, Poland; liebert@ump.edu.pl
AuthorAffiliation_xml – name: Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznań, Poland; liebert@ump.edu.pl
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  surname: Jodynis-Liebert
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29783725$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords rotenone
behavioral tests
urolithins
Language English
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Snippet Parkinson’s disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing....
Parkinson's disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing....
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SubjectTerms animal models
Animals
Antiparkinson Agents - adverse effects
Antiparkinson Agents - metabolism
Antiparkinson Agents - therapeutic use
Behavior, Animal - drug effects
blood-brain barrier
brain
Brain - drug effects
Brain - metabolism
Brain - physiopathology
cognition
Disease Models, Animal
dopamine
histopathology
Humans
immunohistochemistry
in vivo studies
iron
metabolites
Mice
Motor Activity - drug effects
neurons
Neuroprotective Agents - adverse effects
Neuroprotective Agents - metabolism
Neuroprotective Agents - therapeutic use
neuroprotective effect
oxidative stress
Parkinson disease
Parkinson Disease - diagnosis
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Parkinson Disease - psychology
Parkinson's disease
Permeability
Polyphenols
Polyphenols - adverse effects
Polyphenols - metabolism
Polyphenols - therapeutic use
Rats
Review
signal transduction
Systematic review
therapeutics
Treatment Outcome
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Title Polyphenols in Parkinson’s Disease: A Systematic Review of In Vivo Studies
URI https://www.ncbi.nlm.nih.gov/pubmed/29783725
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https://pubmed.ncbi.nlm.nih.gov/PMC5986521
Volume 10
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