Peli1 Modulates the Subcellular Localization and Activity of Mdmx

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 11; pp. 2897 - 2910
• Main Authors: Li, Dawei, Tavana, Omid, Sun, Shao-Cong, Gu, Wei
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 01.06.2018
• Subjects: Animals; Cancer; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cytoplasm; Cytoplasm - metabolism; HEK293 Cells; Humans; Localization; MDM2 protein; Melanoma; Melanoma - metabolism; Melanoma, Cutaneous Malignant; Mice; Myc protein; Nuclear Proteins - metabolism; Nuclei; p53 Protein; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-mdm2 - metabolism; Repressors; Rodents; Skin Neoplasms - metabolism; Tumor Suppressor Protein p53 - metabolism; Tumorigenesis; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Ubiquitination - physiology

Mdm2 and Mdmx, both major repressors of p53 in human cancers, are predominantly localized to the nucleus and cytoplasm, respectively. The mechanism by which subcellular localization of Mdmx is regulated remains unclear. In this study, we identify the E3 ligase Peli1 as a major binding partner and re...