PSCArs2294008 T polymorphism increases the risk of bladder cancer in Bai, Dai, and Han ethnicity in China and a potential mechanism

• Published in: Genes & genomics Vol. 40; no. 5; pp. 531 - 541
• Main Authors: Yang, Junfeng, Li, Wei, Zhang, Zhuorui, Shen, Jie, Zhang, Ningnan, Yang, Min, Yang, Maolin, Yu, Yanhong
• Format: Journal Article
• Language: English
• Published: Seoul The Genetics Society of Korea 01.05.2018; Springer Nature B.V; 한국유전학회
• Subjects: Alleles; Animal Genetics and Genomics; Biomedical and Life Sciences; Bladder cancer; Cancer; Cell cycle; Cell growth; Cell migration; Cell proliferation; China; genotype; Genotype & phenotype; Genotypes; Health risk assessment; Human Genetics; Invasiveness; Life Sciences; Microbial Genetics and Genomics; Minority & ethnic groups; nationalities and ethnic groups; neoplasm cells; Overexpression; Plant Genetics and Genomics; Research Article; Ribonucleic acid; risk; RNA; tissues; urinary bladder neoplasms; 생물학; China; Cell proliferation; PSCA rs2294008 (C/T) polymorphism; Bladder cancer; Over-expression; Cell migration; Cell apoptasis

The aim of this study is to make a comparative evaluation on association of PSCArs2294008 C/T polymorphism with the risk of bladder cancer in Bai, Dai, and Han people in China. A potential mechanism of the T allele risk was also investigated. T allele increased the occurring risk of bladder cancer i...