Defining Falciparum-Malaria-Attributable Severe Febrile Illness in Moderate-to-High Transmission Settings on the Basis of Plasma PfHRP2 Concentration

• Published in: The Journal of infectious diseases Vol. 207; no. 2; pp. 351 - 361
• Main Authors: Hendriksen, Ilse C. E., White, Lisa J., Veenemans, Jacobien, Mtove, George, Woodrow, Charles, Amos, Ben, Saiwaew, Somporn, Gesase, Samwel, Nadjm, Behzad, Silamut, Kamolrat, Joseph, Sarah, Chotivanich, Kesinee, Day, Nicholas P. J., von Seidlein, Lorenz, Verhoef, Hans, Reyburn, Hugh, White, Nicholas J., Dondorp, Arjen M.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.01.2013
• Subjects: Antigens, Protozoan - blood; Biological and medical sciences; Blood; Blood plasma; Child, Preschool; Children; Disease models; Disease transmission; Diseases; Female; Fever - epidemiology; Fever - etiology; Fever - parasitology; Fundamental and applied biological sciences. Psychology; Human protozoal diseases; Humans; Infant; Infectious diseases; Major and Brief Reports; Malaria; Malaria, Falciparum - epidemiology; Malaria, Falciparum - parasitology; Malaria, Falciparum - physiopathology; Malaria, Falciparum - transmission; Male; Medical sciences; Microbiology; Parasitemia; Parasitemia - epidemiology; Parasitemia - parasitology; Parasites; Parasitic diseases; Plasmodium falciparum - pathogenicity; Protozoal diseases; Protozoan Proteins - blood; Severity of Illness Index; Tanzania - epidemiology; Tanzania; Infection; Protozoal disease; Parasitosis; Malaria; Transmission
• ISSN: 0022-1899; 1537-6613; 1537-6613
• DOI: 10.1093/infdis/jis675

Background. In malaria-endemic settings, asymptomatic parasitemia complicates the diagnosis of malaria. Histidine-rich protein 2 (HRP2) is produced by Plasmodium falciparum, and its plasma concentration reflects the total body parasite burden. We aimed to define the malaria-attributable fraction of...