A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

• Published in: Frontiers in oncology Vol. 11; p. 641187
• Main Authors: Allen, Tyler A., Cullen, Mark M., Hawkey, Nathan, Mochizuki, Hiroyuki, Nguyen, Lan, Schechter, Elyse, Borst, Luke, Yoder, Jeffrey A., Freedman, Jennifer A., Patierno, Steven R., Cheng, Ke, Eward, William C., Somarelli, Jason A.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 23.09.2021
• Subjects: angiopellosis; cancer exodus hypothesis; circulating tumor cell cluster; metastasis; Oncology; osteosarcoma; tumor cell extravasation

Metastasis is a multistep process in which cells must detach, migrate/invade local structures, intravasate, circulate, extravasate, and colonize. A full understanding of the complexity of this process has been limited by the lack of ability to study these steps in isolation with detailed molecular a...