CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug

• Published in: Clinical cancer research Vol. 24; no. 3; pp. 674 - 683
• Main Authors: Chung, Man Ki, Jung, Young Ho, Lee, Joon Kyoo, Cho, Soo Youn, Murillo-Sauca, Oihana, Uppaluri, Ravindra, Shin, June Ho, Sunwoo, John B.
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 01.02.2018
• Subjects: Activation; Cancer; Coding; Experimental design; Genotype & phenotype; Head; Head & neck cancer; Human behavior; Invasiveness; Lymph nodes; Mesenchyme; Metastases; Metastasis; Nerve growth factor; Nerve growth factor receptors; Oral squamous cell carcinoma; Phenotypes; Snail protein; Squamous cell carcinoma; Survival; Up-regulation; Xenografts; Xenotransplantation

Purpose: Head and neck squamous cell carcinoma (HNSCC) is comprised of heterogeneous populations of cells, and CD271 (NGFR; p75NTR) has been associated with a tumor-initiating cell subpopulation. This study assessed the role of CD271 in modulating metastatic behavior in HNSCC. Experimental Design: C...