Acute neuroactive drug exposures alter locomotor activity in larval zebrafish

• Published in: Neurotoxicology and teratology Vol. 32; no. 1; pp. 84 - 90
• Main Authors: Irons, T.D, MacPhail, R.C, Hunter, D.L, Padilla, S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2010
• Subjects: Animals; Cocaine; Cocaine - toxicity; d-Amphetamine; Danio rerio; Dextroamphetamine - toxicity; Dose-Response Relationship, Drug; Emergency; Ethanol; Ethanol - toxicity; Larva - drug effects; Locomotor activity; Medical Education; Motor Activity - drug effects; Nervous System - drug effects; Photoperiod; Screening; Toxicity Tests - methods; Zebrafish; Zebrafish - physiology; Screening; Zebrafish; Cocaine; d-Amphetamine; Ethanol; Locomotor activity

Abstract As part of the development of a rapid in vivo screen for prioritization of toxic chemicals, we have begun to characterize the locomotor activity of zebrafish ( Danio rerio ) larvae by assessing the acute effects of prototypic drugs that act on the central nervous system. Initially, we chose...