High-Dose Vitamin C Supplementation as a Legitimate Anti-SARS-CoV-2 Prophylaxis in Healthy Subjects—Yes or No?
Vitamin C has a number of acitvities that could contribute to its immune-modulating effects. The only question is whether we should provide ourselves with only the right level of it, or do we need much more during a pandemic? The possibility of reducing the incidence of viral diseases in a well-nour...
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| Published in | Nutrients Vol. 14; no. 5; p. 979 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
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25.02.2022
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| Abstract | Vitamin C has a number of acitvities that could contribute to its immune-modulating effects. The only question is whether we should provide ourselves with only the right level of it, or do we need much more during a pandemic? The possibility of reducing the incidence of viral diseases in a well-nourished population through the use of dietary supplements based on vitamin C is not supported in the literature. Despite this, the belief that an extra intake of vitamin C can increase the efficacy of the immune system is still popular and vitamin C is advertised as a remedy to prevent infectious disease. This article refers to the justification of the use of vitamin C in high doses as an anti-SARS-CoV-2 prophylaxis in healthy subjects. Does it make sense or not? As it turns out, any effects of vitamin C supplementation may be more prominent when the baseline vitamin C level is low, for example in physically active persons. People with hypovitaminosis C are more likely to respond to vitamin C administration. No studies regarding prevention of COVID-19 with high-dose vitamin C supplementation in healthy subjects were found. |
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| AbstractList | Vitamin C has a number of acitvities that could contribute to its immune-modulating effects. The only question is whether we should provide ourselves with only the right level of it, or do we need much more during a pandemic? The possibility of reducing the incidence of viral diseases in a well-nourished population through the use of dietary supplements based on vitamin C is not supported in the literature. Despite this, the belief that an extra intake of vitamin C can increase the efficacy of the immune system is still popular and vitamin C is advertised as a remedy to prevent infectious disease. This article refers to the justification of the use of vitamin C in high doses as an anti-SARS-CoV-2 prophylaxis in healthy subjects. Does it make sense or not? As it turns out, any effects of vitamin C supplementation may be more prominent when the baseline vitamin C level is low, for example in physically active persons. People with hypovitaminosis C are more likely to respond to vitamin C administration. No studies regarding prevention of COVID-19 with high-dose vitamin C supplementation in healthy subjects were found. Vitamin C has a number of acitvities that could contribute to its immune-modulating effects. The only question is whether we should provide ourselves with only the right level of it, or do we need much more during a pandemic? The possibility of reducing the incidence of viral diseases in a well-nourished population through the use of dietary supplements based on vitamin C is not supported in the literature. Despite this, the belief that an extra intake of vitamin C can increase the efficacy of the immune system is still popular and vitamin C is advertised as a remedy to prevent infectious disease. This article refers to the justification of the use of vitamin C in high doses as an anti-SARS-CoV-2 prophylaxis in healthy subjects. Does it make sense or not? As it turns out, any effects of vitamin C supplementation may be more prominent when the baseline vitamin C level is low, for example in physically active persons. People with hypovitaminosis C are more likely to respond to vitamin C administration. No studies regarding prevention of COVID-19 with high-dose vitamin C supplementation in healthy subjects were found.Vitamin C has a number of acitvities that could contribute to its immune-modulating effects. The only question is whether we should provide ourselves with only the right level of it, or do we need much more during a pandemic? The possibility of reducing the incidence of viral diseases in a well-nourished population through the use of dietary supplements based on vitamin C is not supported in the literature. Despite this, the belief that an extra intake of vitamin C can increase the efficacy of the immune system is still popular and vitamin C is advertised as a remedy to prevent infectious disease. This article refers to the justification of the use of vitamin C in high doses as an anti-SARS-CoV-2 prophylaxis in healthy subjects. Does it make sense or not? As it turns out, any effects of vitamin C supplementation may be more prominent when the baseline vitamin C level is low, for example in physically active persons. People with hypovitaminosis C are more likely to respond to vitamin C administration. No studies regarding prevention of COVID-19 with high-dose vitamin C supplementation in healthy subjects were found. |
| Author | Gruber-Bzura, Beata M. |
| AuthorAffiliation | Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, 00-725 Warsaw, Poland; b.gruber@nil.gov ; Tel.: +48-22-841-39-91 |
| AuthorAffiliation_xml | – name: Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, 00-725 Warsaw, Poland; b.gruber@nil.gov ; Tel.: +48-22-841-39-91 |
| Author_xml | – sequence: 1 givenname: Beata M. surname: Gruber-Bzura fullname: Gruber-Bzura, Beata M. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35267953$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3390/nu12113286 10.1155/2014/173403 10.37358/RC.20.5.8159 10.1007/s13337-020-00643-6 10.3390/nu7042574 10.1016/j.jgar.2020.09.025 10.1016/j.cyto.2004.02.004 10.1182/blood-2010-12-324186 10.1186/s13054-021-03810-3 10.1097/MCC.0000000000000510 10.1111/j.1745-7599.2009.00409.x 10.1136/bmjmilitary-2019-001384 10.3389/fimmu.2020.574029 10.3390/nu5083131 10.1186/s12970-021-00416-6 10.1182/blood-2010-09-307637 10.1159/000434757 10.1089/ars.2012.4988 10.1016/S0014-5793(02)03167-8 10.3390/nu11061363 10.1152/ajpcell.00076.2016 10.3389/fimmu.2021.656039 10.1007/s10787-021-00835-6 10.1007/BF01317848 10.1016/j.crvi.2014.08.003 10.1080/10408398.2020.1744513 10.3390/ijerph10093834 10.1016/j.nut.2020.110948 10.1111/j.1753-4887.2007.tb00298.x 10.1016/j.bbrc.2005.08.193 10.1002/rmv.2261 10.1016/j.jss.2008.04.024 10.1080/13813455.2020.1791188 10.1007/s12263-014-0390-x 10.3390/antiox10020215 10.1201/9780429442025 10.3390/nu9111211 10.3390/nu13020615 10.1177/2164956120934768 10.3389/fimmu.2021.659001 10.1189/jlb.0903415 10.3389/fmed.2020.559811 10.2903/j.efsa.2013.3418 10.1016/j.medidd.2020.100064 10.20944/preprints202010.0407.v2 10.1093/ndt/gfh928 10.1136/bmj.m4912 10.1016/j.freeradbiomed.2014.01.033 10.1136/bmj.n544 10.1016/j.bbrc.2013.04.013 10.3390/nu13030791 10.3390/nu13041172 10.3390/nu12020292 10.7326/0003-4819-140-7-200404060-00010 10.1073/pnas.93.8.3704 10.3390/nu9040339 10.2174/1389557514666140428112602 10.3390/cells8050384 |
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| References | Carr (ref_59) 2020; 61 Feyaerts (ref_50) 2020; 79–80 ref_57 ref_12 Parker (ref_14) 2016; 311 Grzybkowska (ref_39) 2021; 18 ref_54 Vimaleswaran (ref_44) 2021; 372 Bozonet (ref_22) 2015; 7 Ai (ref_38) 2013; 10 Fumeron (ref_13) 2005; 20 Padayatty (ref_58) 2004; 140 Ji (ref_28) 2021; 12 Lorente (ref_49) 2021; 25 Levine (ref_64) 1996; 93 Cerullo (ref_40) 2020; 11 Earar (ref_11) 2020; 71 Rosetti (ref_9) 2020; 61 ref_61 ref_60 (ref_53) 2021; 7 ref_24 ref_23 Heimer (ref_65) 2009; 21 ref_62 Manning (ref_15) 2013; 19 Mansilla (ref_30) 2009; 153 Atherton (ref_52) 1978; 56 Elbers (ref_56) 2018; 24 Elks (ref_33) 2011; 118 Mohammed (ref_21) 2014; 2014 Kumar (ref_18) 2021; 32 Hirota (ref_31) 2005; 338 ref_35 (ref_41) 1997; 67 Ivanov (ref_20) 2021; 14 Webb (ref_25) 2007; 65 Wise (ref_42) 2020; 371 Wilson (ref_3) 2002; 527 Sharma (ref_29) 2004; 75 Goc (ref_19) 2021; 4 Chalker (ref_63) 2021; 12 Hoang (ref_51) 2020; 23 Canali (ref_10) 2014; 9 Guz (ref_36) 2017; 71 Strunk (ref_37) 2004; 27 Redwan (ref_46) 2014; 337 Sinopoli (ref_43) 2021; 32 Nytko (ref_32) 2011; 117 Furuya (ref_17) 2008; 22 Anderson (ref_26) 1979; 56 ref_1 ref_2 Menshawey (ref_47) 2021; 29 ref_48 Arvinte (ref_55) 2020; 8 ref_8 ref_5 ref_4 ref_7 Sorice (ref_16) 2014; 14 Kuiper (ref_34) 2014; 69 Ishikawa (ref_45) 2013; 434 ref_6 Mohammed (ref_27) 2013; 5 |
| References_xml | – ident: ref_6 doi: 10.3390/nu12113286 – volume: 2014 start-page: 173403 year: 2014 ident: ref_21 article-title: Resolution of sterile inflammation: Role of vitamin C publication-title: Mediators Inflamm. doi: 10.1155/2014/173403 – volume: 71 start-page: 473 year: 2020 ident: ref_11 article-title: Biochemical effects and therapeutic application of vitamin C (C6H8O6) on COVID-19 infection publication-title: Rev. Chim. doi: 10.37358/RC.20.5.8159 – volume: 32 start-page: 29 year: 2021 ident: ref_18 article-title: In silico virtual screening-based study of nutraceuticals predicts the therapeutic potentials of folic acid and its derivatives against COVID-10 publication-title: VirusDisease doi: 10.1007/s13337-020-00643-6 – volume: 7 start-page: 2574 year: 2015 ident: ref_22 article-title: Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold Kiwifruit publication-title: Nutrients doi: 10.3390/nu7042574 – volume: 23 start-page: 256 year: 2020 ident: ref_51 article-title: Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection publication-title: J. Glob. Antimicrob. Resist. doi: 10.1016/j.jgar.2020.09.025 – volume: 27 start-page: 101 year: 2004 ident: ref_37 article-title: Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes publication-title: Cytokine doi: 10.1016/j.cyto.2004.02.004 – volume: 118 start-page: 712 year: 2011 ident: ref_33 article-title: Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model publication-title: Blood doi: 10.1182/blood-2010-12-324186 – volume: 25 start-page: 390 year: 2021 ident: ref_49 article-title: Metabolomic differences between COVID-19 and H1N1 influenza induced ARDS publication-title: Crit. Care doi: 10.1186/s13054-021-03810-3 – volume: 24 start-page: 248 year: 2018 ident: ref_56 article-title: Vitamin C: Should we supplement? publication-title: Curr. Opin. Crit. Care doi: 10.1097/MCC.0000000000000510 – volume: 21 start-page: 295 year: 2009 ident: ref_65 article-title: Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold publication-title: J. Am. Acad. Nurse Pract. doi: 10.1111/j.1745-7599.2009.00409.x – ident: ref_62 doi: 10.1136/bmjmilitary-2019-001384 – volume: 11 start-page: 574029 year: 2020 ident: ref_40 article-title: The long history of vitamin C: From prevention of the common cold to potential aid in the treatment of COVID-19 publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.574029 – volume: 5 start-page: 3131 year: 2013 ident: ref_27 article-title: Vitamin C: A novel regulator of neutrophil extracellular trap formation publication-title: Nutrients doi: 10.3390/nu5083131 – volume: 18 start-page: 19 year: 2021 ident: ref_39 article-title: Effect of six weeks 1000 mg/day vitamin C supplementation and healthy training in elderly women on genes expression associated with the immune reponse—a randomized controlled trial publication-title: J. Int. Soc. Sports Nutr. doi: 10.1186/s12970-021-00416-6 – volume: 117 start-page: 5485 year: 2011 ident: ref_32 article-title: Vitamin C is dispensable for oxygen sensing in vivo publication-title: Blood doi: 10.1182/blood-2010-09-307637 – ident: ref_61 doi: 10.1159/000434757 – volume: 19 start-page: 2054 year: 2013 ident: ref_15 article-title: Vitamin C promotes maturation of T-cells publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2012.4988 – volume: 527 start-page: 5 year: 2002 ident: ref_3 article-title: The physiological role of dehydroascorbic acid publication-title: FEBS Lett. doi: 10.1016/S0014-5793(02)03167-8 – ident: ref_24 doi: 10.3390/nu11061363 – volume: 311 start-page: C652 year: 2016 ident: ref_14 article-title: Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00076.2016 – volume: 4 start-page: 87 year: 2021 ident: ref_19 article-title: Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants publication-title: Eur. J. Microbiol. Immunol. – volume: 56 start-page: 429 year: 1979 ident: ref_26 article-title: Effects of ascorbate on leucocytes: Part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate publication-title: S. Afr. Med. J. – volume: 12 start-page: 625 year: 2021 ident: ref_28 article-title: Neutrophil in reverse migration: Role in sepsis publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.656039 – volume: 29 start-page: 1017 year: 2021 ident: ref_47 article-title: Shedding light on vitamin D: The shared mechanistic and pathophysiological role between hypovitaminosis D and COVID-19 risk factors and complications publication-title: Inflammopharmacology doi: 10.1007/s10787-021-00835-6 – volume: 56 start-page: 195 year: 1978 ident: ref_52 article-title: The effect of ascorbic acid on infection of chick-embryo ciliated tracheal organ cultures by coronavirus publication-title: Arch. Virol. doi: 10.1007/BF01317848 – volume: 337 start-page: 581 year: 2014 ident: ref_46 article-title: Potential lactoferrin activity against pathogenic viruses publication-title: Comptes Rendus Biol. doi: 10.1016/j.crvi.2014.08.003 – volume: 61 start-page: 742 year: 2020 ident: ref_59 article-title: Discrepancies in global vitamin C recommendations: A review of RDA criteria and underlying health perspectives publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2020.1744513 – volume: 61 start-page: 145 year: 2020 ident: ref_9 article-title: High dose of ascorbic acid used in Sars Covid-19 treatment: Scientific and clinical support for its therapeutic implementation publication-title: Ars. Pharm. – volume: 10 start-page: 3834 year: 2013 ident: ref_38 article-title: Optimal method to stimulate cytokine production and its use in immunotoxicity assessment publication-title: Int. J. Environ. Res. Public Health doi: 10.3390/ijerph10093834 – volume: 79–80 start-page: 110948 year: 2020 ident: ref_50 article-title: Vitamin C as prophylaxis and adjunctive medical treatment for COVID-10? publication-title: Nutrition doi: 10.1016/j.nut.2020.110948 – volume: 71 start-page: 747 year: 2017 ident: ref_36 article-title: The role of vitamin C in epigenetic regulation publication-title: Post. Hig. Med. Dosw. – volume: 65 start-page: 181 year: 2007 ident: ref_25 article-title: Update: Effects of antioxidant and non-antioxidant vitamin supplementation on immune function publication-title: Nutr. Rev. doi: 10.1111/j.1753-4887.2007.tb00298.x – volume: 338 start-page: 610 year: 2005 ident: ref_31 article-title: Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2005.08.193 – volume: 32 start-page: e2261 year: 2021 ident: ref_43 article-title: The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review publication-title: Rev. Med. Virol. doi: 10.1002/rmv.2261 – volume: 153 start-page: 224 year: 2009 ident: ref_30 article-title: Effect of vitamin C administration on neutrophil apoptosis in septic patients after abdominal surgery publication-title: J. Surg. Res. doi: 10.1016/j.jss.2008.04.024 – volume: 14 start-page: 1 year: 2021 ident: ref_20 article-title: Inhibition of ACE2 expression by ascorbic acid alone and its combinations with other natural compounds publication-title: Inf. Dis. Res. Treat. – volume: 67 start-page: 329 year: 1997 ident: ref_41 article-title: Vitamin C supplementation and the common cold-was Linus Pauling right or wrong? publication-title: Int. J. Vitam. Nutr. Res. – ident: ref_48 doi: 10.1080/13813455.2020.1791188 – volume: 9 start-page: 390 year: 2014 ident: ref_10 article-title: Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus: A pilot study in healthy subjects publication-title: Genes Nutr. doi: 10.1007/s12263-014-0390-x – volume: 22 start-page: 541 year: 2008 ident: ref_17 article-title: Antiviral effects of ascorbic and dehydroascorbic acids in vitro publication-title: Int. J. Mol. Med. – ident: ref_2 doi: 10.3390/antiox10020215 – ident: ref_23 doi: 10.1201/9780429442025 – ident: ref_4 doi: 10.3390/nu9111211 – ident: ref_1 doi: 10.3390/nu13020615 – ident: ref_57 doi: 10.1177/2164956120934768 – volume: 12 start-page: 659001 year: 2021 ident: ref_63 article-title: Commentary: The long history of vitamin C: From prevention of the common cold to potential aid in the treatment of COVID-19 publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.659001 – volume: 75 start-page: 1070 year: 2004 ident: ref_29 article-title: Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: Modulatory effect of nitric oxide publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0903415 – volume: 7 start-page: 559811 year: 2021 ident: ref_53 article-title: Vitamin C and COVID-19 publication-title: Front. Med. doi: 10.3389/fmed.2020.559811 – ident: ref_60 doi: 10.2903/j.efsa.2013.3418 – volume: 8 start-page: 100064 year: 2020 ident: ref_55 article-title: Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a North American Community Hospital Intensive Care Unit in May 2020: A pilot study publication-title: Med. Drug Discov. doi: 10.1016/j.medidd.2020.100064 – ident: ref_7 doi: 10.20944/preprints202010.0407.v2 – volume: 20 start-page: 1874 year: 2005 ident: ref_13 article-title: Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients publication-title: Nephrol. Dial. Transplant. doi: 10.1093/ndt/gfh928 – volume: 371 start-page: m4912 year: 2020 ident: ref_42 article-title: COVID-19: Evidence is lacking to support vitamin D’s role in treatment and prevention publication-title: BMJ doi: 10.1136/bmj.m4912 – volume: 69 start-page: 308 year: 2014 ident: ref_34 article-title: Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2014.01.033 – volume: 372 start-page: n544 year: 2021 ident: ref_44 article-title: Vitamin D and covid-10 publication-title: BMJ doi: 10.1136/bmj.n544 – volume: 434 start-page: 791 year: 2013 ident: ref_45 article-title: The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2013.04.013 – ident: ref_12 doi: 10.3390/nu13030791 – ident: ref_54 doi: 10.3390/nu13041172 – ident: ref_8 doi: 10.3390/nu12020292 – volume: 140 start-page: 533 year: 2004 ident: ref_58 article-title: Vitamin C pharmacokinetics: Implications for oral and intravenous use publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-140-7-200404060-00010 – volume: 93 start-page: 3704 year: 1996 ident: ref_64 article-title: Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowances publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.93.8.3704 – ident: ref_5 doi: 10.3390/nu9040339 – volume: 14 start-page: 444 year: 2014 ident: ref_16 article-title: Ascorbic acid: Its role in immune system and chronic inflammation diseases publication-title: Mini Rev. Med. Chem. doi: 10.2174/1389557514666140428112602 – ident: ref_35 doi: 10.3390/cells8050384 |
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| SubjectTerms | Ascorbic Acid Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 infection Dietary Supplements disease prevention Healthy Volunteers Humans immune system immunomodulators pandemic people Review SARS-CoV-2 Viral infections Vitamin C vitamin deficiencies |
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| Title | High-Dose Vitamin C Supplementation as a Legitimate Anti-SARS-CoV-2 Prophylaxis in Healthy Subjects—Yes or No? |
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