Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial

To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50–69 years with overweight or preh...

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Published inNutrients Vol. 11; no. 8; p. 1822
Main Authors Uchio, Ryusei, Muroyama, Koutarou, Okuda-Hanafusa, Chinatsu, Kawasaki, Kengo, Yamamoto, Yoshihiro, Murosaki, Shinji
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 07.08.2019
MDPI
Subjects
Aged
anti-inflammatory agents
Biomarkers - blood
Blood & organ donations
Blood pressure
blood serum
C-reactive protein
Cell adhesion & migration
Clinical trials
Curcuma - chemistry
Curcuma longa
Cyclohexanols - administration & dosage
Disease
Double-Blind Method
Double-blind studies
elderly
emotions
glucose
glycohemoglobin
health surveys
Hepatitis
high density lipoprotein cholesterol
Humans
Hypertension
Hypertension - blood
Inflammation
Inflammation - blood
interleukin-6
Mental Health
metabolic diseases
Metabolism
Middle age
Middle Aged
Obesity
overweight
Overweight - blood
Placebos
Plant Extracts - pharmacology
Prehypertension - blood
R&D
randomized clinical trials
Research & development
Sesquiterpenes - administration & dosage
Sleep
triacylglycerols
tumor necrosis factor-alpha
Tumor necrosis factor-TNF
vascular cell adhesion molecules
Water
Womens health
Japan
profile of mood states
glucose
short-form 36-item health survey
C-reactive protein
bisacurone
turmeric (Curcuma longa L.)
turmeronol
hemoglobin A1c
high-density cholesterol
chronic inflammation
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Abstract To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50–69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.
AbstractList Recently, turmeronol A and B isolated from WEC were found to inhibit production of inflammatory mediators, including prostaglandin E2 and nitric oxide, by activated macrophages [54]. [...]it is possible that WEC reduces the production of inflammatory mediators, hepatic infiltration of monocytes/macrophages, and production of CRP, resulting in the suppression of low-grade inflammation. According to the World Health Organization, QOL is defined as individual’s perception of their position in life embedded in a cultural, social, and environmental context [59]. Using the Trier Social Stress Test, tasks that induce psychological stress were associated with an elevated systemic IL-6 level and a decrease of the POMS F score [74,75]. [...]a clinical study has shown that anti-inflammatory foods improve the scores for positive mood states (VA and F) [76,77]. C. longa was reported to have the potential to reduce the production of inflammatory mediators such as nitric oxide and ameliorate anxiety- and sleep deprivation-induced behavior abnormalities in a stressed animal [78,79]. [...]WEC may increase the POMS scores for positive mood states by reducing the levels of inflammatory mediators. 5.
To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.
To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50–69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.
To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50–69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.
To investigate the effect of a hot water extract of L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 μg bisacurone, 80 μg turmeronol A and 20 μg turmeronol B (WEC group: = 45), or placebo tablets without WEC (placebo group: = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.
Author Kawasaki, Kengo
Yamamoto, Yoshihiro
Okuda-Hanafusa, Chinatsu
Murosaki, Shinji
Uchio, Ryusei
Muroyama, Koutarou
AuthorAffiliation Research & Development Institute, House Wellness Foods Corp., 3-20 Imoji, Itami, Hyogo 664-0011, Japan
AuthorAffiliation_xml – name: Research & Development Institute, House Wellness Foods Corp., 3-20 Imoji, Itami, Hyogo 664-0011, Japan
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  orcidid: 0000-0001-5924-4534
  surname: Uchio
  fullname: Uchio, Ryusei
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  givenname: Koutarou
  surname: Muroyama
  fullname: Muroyama, Koutarou
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  givenname: Chinatsu
  surname: Okuda-Hanafusa
  fullname: Okuda-Hanafusa, Chinatsu
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  givenname: Kengo
  surname: Kawasaki
  fullname: Kawasaki, Kengo
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  givenname: Yoshihiro
  surname: Yamamoto
  fullname: Yamamoto, Yoshihiro
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  givenname: Shinji
  surname: Murosaki
  fullname: Murosaki, Shinji
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31394768$$D View this record in MEDLINE/PubMed
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Issue 8
Keywords profile of mood states
glucose
short-form 36-item health survey
C-reactive protein
bisacurone
turmeric (Curcuma longa L.)
turmeronol
hemoglobin A1c
high-density cholesterol
chronic inflammation
Language English
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SSID ssj0000070763
Score 2.3665223
Snippet To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation,...
To investigate the effect of a hot water extract of L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a...
Recently, turmeronol A and B isolated from WEC were found to inhibit production of inflammatory mediators, including prostaglandin E2 and nitric oxide, by...
To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation,...
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pubmed
crossref
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StartPage 1822
SubjectTerms Aged
anti-inflammatory agents
Biomarkers - blood
Blood & organ donations
Blood pressure
blood serum
C-reactive protein
Cell adhesion & migration
Clinical trials
Curcuma - chemistry
Curcuma longa
Cyclohexanols - administration & dosage
Disease
Double-Blind Method
Double-blind studies
elderly
emotions
glucose
glycohemoglobin
health surveys
Hepatitis
high density lipoprotein cholesterol
Humans
Hypertension
Hypertension - blood
Inflammation
Inflammation - blood
interleukin-6
Mental Health
metabolic diseases
Metabolism
Middle age
Middle Aged
Obesity
overweight
Overweight - blood
Placebos
Plant Extracts - pharmacology
Prehypertension - blood
R&D
randomized clinical trials
Research & development
Sesquiterpenes - administration & dosage
Sleep
triacylglycerols
tumor necrosis factor-alpha
Tumor necrosis factor-TNF
vascular cell adhesion molecules
Water
Womens health
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Title Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory Markers and General Health in Subjects with Overweight or Prehypertension/Mild Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial
URI https://www.ncbi.nlm.nih.gov/pubmed/31394768
https://www.proquest.com/docview/2302380060
https://www.proquest.com/docview/2270005941
https://www.proquest.com/docview/2315264496
https://pubmed.ncbi.nlm.nih.gov/PMC6723939
Volume 11
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