Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas

• Published in: Molecular cancer therapeutics Vol. 16; no. 8; pp. 1456 - 1469
• Main Authors: King, Amanda R., Corso, Christopher D., Chen, Evan M., Song, Eric, Bongiorni, Paul, Chen, Zhe, Sundaram, Ranjini K., Bindra, Ranjit S., Saltzman, W. Mark
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 01.08.2017
• Subjects: Animals; Brain; Brain Stem Neoplasms - drug therapy; Brain Stem Neoplasms - pathology; Brain tumors; Cell Line, Tumor; Chemotherapy; Convection; Delivery scheduling; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA repair; DNA Repair - drug effects; Drug Delivery Systems; Endocytosis - drug effects; Glioblastoma; Glioma; Glioma - drug therapy; Glioma - pathology; Humans; Male; Medical treatment; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Polyesters - chemistry; Polyethylene Glycols - chemistry; Radiation; Radiation therapy; Radiation-Sensitizing Agents - pharmacology; Radiation-Sensitizing Agents - therapeutic use; Radiosensitization; Radiosensitizers; Rats; Rats, Inbred F344; Surgery; Synergistic effect; Tissue Distribution - drug effects; Toxicity; Tumors

High-grade gliomas, such as glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG), are characterized by an aggressive phenotype with nearly universal local disease progression despite multimodal treatment, which typically includes chemotherapy, radiotherapy, and possibly surgery. Radiosensi...