Prophylactic exercise-derived circulating exosomal miR-125a-5p promotes endogenous revascularization after hindlimb ischemia by targeting endothelin converting enzyme 1

• Published in: Frontiers in cardiovascular medicine Vol. 9; p. 881526
• Main Authors: Qiu, Xueting, Zhou, Jipeng, Xu, Yanying, Liao, Longsheng, Yang, Huijun, Xiang, Yuan, Zhou, Zhengshi, Sun, Quan, Chen, Minghong, Zhang, Jiaxiong, Wu, Wanzhou, Zhu, Lingping, You, Baiyang, He, Lingfang, Luo, Ying, Li, Zhenyu, Li, Chuanchang, Bai, Yongping
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 22.07.2022
• Subjects: Cardiovascular Medicine; circulating; exercise; exosome; miR-125a-5p; revascularization

Prophylactic exercise improves clinical outcomes in patients experiencing severe ischemic diseases. Previous studies have shown that exercise could alter the amount or content of circulating exosomes. However, little is known about the role of precursory exercise-derived circulating exosomes (Exe-Ex...