Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes

• Published in: Anticancer research Vol. 41; no. 1; pp. 55 - 70
• Main Authors: MORIYAMA, HITOMI, DAINO, KAZUHIRO, ISHIKAWA, ATSUKO, IMAOKA, TATSUHIKO, NISHIMURA, MAYUMI, NISHIMURA, YUKIKO, TAKABATAKE, MASARU, MORIOKA, TAKAMITSU, INOUE, KAZUMASA, FUKUSHI, MASAHIRO, SHIMADA, YOSHIYA, KAKINUMA, SHIZUKO
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.01.2021
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Biopsy; Breast cancer; Cancer; Cloning; Computational Biology - methods; DNA Copy Number Variations - radiation effects; DNA Methylation; DNA Mutational Analysis; Exome; Experiments; Female; Gamma rays; Genes; Genetic testing; Health risks; Humans; Immunohistochemistry; INDEL Mutation; Mammary gland; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - pathology; Mammary Neoplasms, Experimental - radiotherapy; Mutation; Mutation - radiation effects; Neoplasms, Radiation-Induced - genetics; Neoplasms, Radiation-Induced - pathology; Neutrons; Nuclear accidents & safety; Point mutation; Radiation; Radiation effects; Radiation, Ionizing; Rats; Rodents; Signal transduction; Statistical analysis; Tumorigenesis; Tumors; Whole Exome Sequencing; Whole genome sequencing; Wnt protein; β-Catenin; United States > US; Japan; Germany; breast cancer; Neutron; genomic aberrations

Our understanding of cancer risk from neutron exposure is limited. We aimed to reveal the characteristics of mammary carcinomas induced by neutrons. Mammary carcinomas obtained from female Sprague-Dawley rats irradiated at 7 weeks of age with 0.97 Gy neutrons or 4 Gy γ-rays and from non-irradiated r...