PD-L1 Studies Across Tumor Types, Its Differential Expression and Predictive Value in Patients Treated with Immune Checkpoint Inhibitors

• Published in: Clinical cancer research Vol. 23; no. 15; pp. 4270 - 4279
• Main Authors: Kluger, Harriet M., Zito, Christopher R., Turcu, Gabriela, Baine, Marina K., Zhang, Hongyi, Adeniran, Adebowale, Sznol, Mario, Rimm, David L., Kluger, Yuval, Chen, Lieping, Cohen, Justine V., Jilaveanu, Lucia B.
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 01.08.2017
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies; Antibodies, Monoclonal - administration & dosage; Antineoplastic Agents - administration & dosage; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - genetics; B7-H1 Antigen - immunology; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - immunology; Biotechnology; Cancer; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - immunology; Carcinoma, Renal Cell - pathology; CTLA-4 protein; Experimental design; Female; Gene Expression Regulation, Neoplastic - drug effects; Humans; Immune checkpoint; Immunofluorescence; Inflammation; Inhibitors; Lung cancer; Male; Melanoma; Melanoma - drug therapy; Melanoma - genetics; Melanoma - immunology; Melanoma - pathology; Middle Aged; Monoclonal antibodies; Non-small cell lung carcinoma; Patients; PD-1 protein; PD-L1 protein; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - immunology; Renal cell carcinoma; Studies; Targeted cancer therapy; Tissue Array Analysis; Tumor cells; Tumors

Purpose: With recent approval of inhibitors of PD-1 in melanoma, non–small cell lung cancer (NSCLC) and renal cell carcinoma, extensive efforts are under way to develop biomarkers predictive of response. PD-L1 expression has been most widely studied, and is more predictive in NSCLC than renal cell c...