Concentration-response gene expression analysis in zebrafish reveals phenotypically-anchored transcriptional responses to retene

• Published in: Frontiers in toxicology Vol. 4; p. 950503
• Main Authors: Wilson, Lindsay B., McClure, Ryan S., Waters, Katrina M., Simonich, Michael T., Tanguay, Robyn L.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 25.08.2022
• Subjects: benchmark concentration; phenotypic anchoring; polycyclic aromatic hydrocarbon (PAH); retene; toxicogenomics; Toxicology; zebrafish

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants and are associated with human disease. Canonically, many PAHs induce toxicity via activation of the aryl hydrocarbon receptor (AHR) pathway. While the interaction between PAHs and the AHR is well-established, understan...