Comparing the efficacies of two chemo-mechanical caries removal agents (2.25% sodium hypochlorite gel and brix 3000), in caries removal and patient cooperation: A randomized controlled clinical trial

• Published in: Journal of dentistry Vol. 93; p. 103280
• Main Authors: Alkhouli, Muaaz M., Al Nesser, Salma F., Bshara, Nada G., AlMidani, Awab N., Comisi, John C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2020; Elsevier Limited
• Subjects: Acceptance tests; Amino acids; Caries; Caries removal; Chemo-mechanical caries removal; Children; Clinical trials; Collagen; Control methods; Cooperation; Dental caries; Dentin; Dentistry; Free surfaces; Low speed; Methods; Minimally invasive dentistry; Molars; Null hypothesis; Pain; Randomization; Sodium; Sodium hypochlorite; Sodium hypochlorite gel; Teeth; Trauma; United States > US; Argentina; Germany; Chemo-mechanical caries removal; Caries; Caries removal; Sodium hypochlorite gel; Minimally invasive dentistry
• DOI: 10.1016/j.jdent.2020.103280
• ISSN: 0300-5712; 1879-176X

This study compared and evaluated the effectiveness of Brix 3000 and 2.25 % sodium hypochlorite (NaOCl) gel with conventional rotary instrumentation method in caries excavation of primary molars. The null hypothesis: no difference between the two tested chemo-mechanical caries removal (CMCR) agents used in this trial. a randomized controlled clinical trial conducted with 32 children suffering from proximal caries of primary maxillary molars, age ranging between 6 and 9 years old. Subjects were randomly assigned into three groups: Brix 3000, NaOCl gel, and conventional with 10, 12, and 10 teeth in each group, respectively. After isolation of selected teeth, either CMCR agent were applied for two minutes. The application was repeated as needed until a caries-free surface was obtained. The conventional group used low-speed burs to excavate all carious lesions. The time required to obtain a caries-free result for each testing method was recorded. Wong-Baker FACES pain rating scale was used to assess the acceptance of the technique used by the child. Conventional treatment required significantly less time for caries removal compared to Brix 3000 (P = .002) and NaOCl gel (P = .000). No significant difference observed between Brix 3000 and NaOCl gel (P = .679). Statistically higher pain scores were observed with conventional treatment compared to both Brix 3000 (P = .000) and NaOCl gel (P = .005). Pain scores were lower with Brix 3000, and NaOCl gel with no significant difference observed between the CMCR agents (p = .690). CMCR agents that are effective in removing the carious dentine of primary teeth without negatively affecting the cooperation of children. The use of a 2.25 % sodium hypochlorite gel can be an effective and well-tolerated method of removing decay from primary teeth and reduce the trauma associated with conventional rotary caries removal.