Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone
We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated...
Saved in:
| Published in | Immunity (Cambridge, Mass.) Vol. 34; no. 6; pp. 947 - 960 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
24.06.2011
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell immigration preceding B cells by 1 day. Notably, in the absence of cognate B cells, Tfh cells still formed and migrated to the follicle. However, without such B cells, PD-1, ICOS, and GL7 were no longer expressed on follicular Bcl6
hi T cells that nevertheless persisted in the follicle. Thus, Ag-specific B cells are required for the maintenance of the PD-1
hiICOS
hiGL7
hi Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone.
► After immunization, responding T and B cells home to and interact in the IF zone ► GC B cell and Tfh cell commitment in the IF zone precedes entry into the follicle ► The Tfh cell phenotype is induced globally, but maintained on only a subset of T cells ► Tfh cells differentiate, but are not maintained, in the absence of cognate B cells |
|---|---|
| AbstractList | We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell immigration preceding B cells by 1 day. Notably, in the absence of cognate B cells, Tfh cells still formed and migrated to the follicle. However, without such B cells, PD-1, ICOS, and GL7 were no longer expressed on follicular Bcl6
hi T cells that nevertheless persisted in the follicle. Thus, Ag-specific B cells are required for the maintenance of the PD-1
hiICOS
hiGL7
hi Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone.
► After immunization, responding T and B cells home to and interact in the IF zone ► GC B cell and Tfh cell commitment in the IF zone precedes entry into the follicle ► The Tfh cell phenotype is induced globally, but maintained on only a subset of T cells ► Tfh cells differentiate, but are not maintained, in the absence of cognate B cells We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell immigration preceding B cells by 1 day. Notably, in the absence of cognate B cells, Tfh cells still formed and migrated to the follicle. However, without such B cells, PD-1, ICOS, and GL7 were no longer expressed on follicular Bcl6(hi) T cells that nevertheless persisted in the follicle. Thus, Ag-specific B cells are required for the maintenance of the PD-1(hi)ICOS(hi)GL7(hi) Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone.We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell immigration preceding B cells by 1 day. Notably, in the absence of cognate B cells, Tfh cells still formed and migrated to the follicle. However, without such B cells, PD-1, ICOS, and GL7 were no longer expressed on follicular Bcl6(hi) T cells that nevertheless persisted in the follicle. Thus, Ag-specific B cells are required for the maintenance of the PD-1(hi)ICOS(hi)GL7(hi) Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone. We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell immigration preceding B cells by 1 day. Notably, in the absence of cognate B cells, Tfh cells still formed and migrated to the follicle. However, without such B cells, PD-1, ICOS, and GL7 were no longer expressed on follicular Bcl6 super(hi) T cells that nevertheless persisted in the follicle. Thus, Ag-specific B cells are required for the maintenance of the PD-1 super(hi)ICOS super(hi)GL7 super(hi) Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone. We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell immigration preceding B cells by 1 day. Notably, in the absence of cognate B cells, Tfh cells still formed and migrated to the follicle. However, without such B cells, PD-1, ICOS, and GL7 were no longer expressed on follicular Bcl6(hi) T cells that nevertheless persisted in the follicle. Thus, Ag-specific B cells are required for the maintenance of the PD-1(hi)ICOS(hi)GL7(hi) Tfh cell phenotype within the follicle, but not for their initial differentiation in the IF zone. |
| Author | Gonzalez, David G. Kleinstein, Steven H. Yaari, Gur Johnson, Kody L. Kerfoot, Steven M. Haberman, Ann M. Patel, Jaymin R. |
| Author_xml | – sequence: 1 givenname: Steven M. surname: Kerfoot fullname: Kerfoot, Steven M. organization: Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 2 givenname: Gur surname: Yaari fullname: Yaari, Gur organization: Department of Pathology, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 3 givenname: Jaymin R. surname: Patel fullname: Patel, Jaymin R. organization: Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 4 givenname: Kody L. surname: Johnson fullname: Johnson, Kody L. organization: Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 5 givenname: David G. surname: Gonzalez fullname: Gonzalez, David G. organization: Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 6 givenname: Steven H. surname: Kleinstein fullname: Kleinstein, Steven H. organization: Department of Pathology, Yale School of Medicine, New Haven, CT 06519, USA – sequence: 7 givenname: Ann M. surname: Haberman fullname: Haberman, Ann M. email: ann.haberman@yale.edu organization: Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06519, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21636295$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU2LFDEQhoOsuB_6D0Ry89RtpZPuTjwIOrofsOBlvXgJmXQFM6TTY5Je8N-bcXYRPLinKqre56Wo95ycxCUiIa8ZtAzY8G7X-nleo287YKwF3kInnpEzBmpsBJNwcuhH0YwD46fkPOcdABO9ghfktGMDHzrVnxG8wjT7aALdYCyY6KfahEBNnOgdvVxC8HYNJtFrDPu6_rP8jPcYlv1cCXoTffGmYKY-0vID66DauL_g93r2S_LcmZDx1UO9IN8uv9xtrpvbr1c3m4-3jRVclUY6ud2iAjkOrhsnNY3CCKm4BatMzyWXvUPBYEK5hd7CJBk4kIODvnMjcn5B3h5992n5uWIuevbZ1pNNxGXNWnUgQXSgnlTKUQCTQomqfPOgXLczTnqf_GzSL_34wyp4fxTYtOSc0Gnriyl-iSUZHzQDfQhM7_QxMH0ITAPXNbAKi3_gR_8nsA9HDOs37z0mna3HaHHyCW3R0-L_b_AbB52wkQ |
| CitedBy_id | crossref_primary_10_1038_srep25840 crossref_primary_10_1016_j_isci_2023_106310 crossref_primary_10_1093_intimm_dxt060 crossref_primary_10_3389_fimmu_2016_00474 crossref_primary_10_1084_jem_20221483 crossref_primary_10_1111_cei_12702 crossref_primary_10_3390_pathogens11050523 crossref_primary_10_1111_j_1600_065X_2012_01125_x crossref_primary_10_1111_imr_12859 crossref_primary_10_1111_imr_12739 crossref_primary_10_1038_s41467_020_17293_3 crossref_primary_10_1038_s41590_024_01986_8 crossref_primary_10_1111_imr_12743 crossref_primary_10_1038_jhg_2016_88 crossref_primary_10_1128_IAI_00688_13 crossref_primary_10_1371_journal_ppat_1004106 crossref_primary_10_3389_fimmu_2019_01845 crossref_primary_10_1155_2017_9198328 crossref_primary_10_1111_imr_12740 crossref_primary_10_1172_JCI127967 crossref_primary_10_4049_jimmunol_1801626 crossref_primary_10_1111_imr_12862 crossref_primary_10_4049_jimmunol_1201143 crossref_primary_10_1111_imr_12742 crossref_primary_10_1146_annurev_pathmechdis_070323_124158 crossref_primary_10_1038_ni_3054 crossref_primary_10_1038_srep25051 crossref_primary_10_1038_ni_3050 crossref_primary_10_1615_CritRevImmunol_2022045746 crossref_primary_10_1016_j_jneuroim_2014_12_008 crossref_primary_10_1111_acel_13295 crossref_primary_10_1111_imcb_12283 crossref_primary_10_1002_JLB_1RI0121_066R crossref_primary_10_4049_jimmunol_1701217 crossref_primary_10_1016_j_cell_2020_08_025 crossref_primary_10_1016_j_smim_2023_101817 crossref_primary_10_3390_v10060336 crossref_primary_10_1038_embor_2012_111 crossref_primary_10_1007_s11427_015_4919_z crossref_primary_10_1016_j_cej_2022_134782 crossref_primary_10_1016_j_coi_2014_01_016 crossref_primary_10_1111_imr_12735 crossref_primary_10_1038_srep18738 crossref_primary_10_4049_jimmunol_1203211 crossref_primary_10_1111_imr_12731 crossref_primary_10_1038_s41467_024_51590_5 crossref_primary_10_1016_j_cellimm_2022_104639 crossref_primary_10_1038_ncomms16037 crossref_primary_10_4049_immunohorizons_2000005 crossref_primary_10_4049_jimmunol_1600993 crossref_primary_10_1097_PAS_0b013e318268d9ff crossref_primary_10_1128_IAI_00333_12 crossref_primary_10_1182_bloodadvances_2019000650 crossref_primary_10_3389_fimmu_2017_01639 crossref_primary_10_1038_ncomms15072 crossref_primary_10_3389_fimmu_2021_682749 crossref_primary_10_1084_jem_20170901 crossref_primary_10_1126_sciimmunol_abi4710 crossref_primary_10_1016_j_exger_2013_12_013 crossref_primary_10_1128_JVI_02077_13 crossref_primary_10_1371_journal_pone_0155311 crossref_primary_10_1016_j_coviro_2013_05_015 crossref_primary_10_1016_j_ebiom_2016_06_047 crossref_primary_10_1093_intimm_dxaa012 crossref_primary_10_1186_s12974_015_0334_4 crossref_primary_10_1007_s00281_022_00971_3 crossref_primary_10_1016_j_it_2014_02_010 crossref_primary_10_1038_s41422_021_00531_8 crossref_primary_10_3389_fimmu_2018_02612 crossref_primary_10_4049_jimmunol_1602042 crossref_primary_10_1038_nri3128 crossref_primary_10_1007_s10875_016_0268_3 crossref_primary_10_3389_fimmu_2018_01884 crossref_primary_10_4049_jimmunol_1103501 crossref_primary_10_1038_nri3804 crossref_primary_10_1016_j_intimp_2021_107434 crossref_primary_10_4049_jimmunol_1300244 crossref_primary_10_4049_jimmunol_1301454 crossref_primary_10_1111_imr_12040 crossref_primary_10_1016_S1169_8330_16_30201_0 crossref_primary_10_3389_fimmu_2015_00297 crossref_primary_10_1016_j_ajur_2020_06_004 crossref_primary_10_1146_annurev_cellbio_100913_013254 crossref_primary_10_1016_j_celrep_2016_06_063 crossref_primary_10_1097_MOT_0b013e32836331b4 crossref_primary_10_1084_jem_20120219 crossref_primary_10_3389_fimmu_2021_679909 crossref_primary_10_1002_eji_202350736 crossref_primary_10_1111_imr_12945 crossref_primary_10_1111_j_1600_065X_2012_01114_x crossref_primary_10_1016_j_molimm_2015_10_003 crossref_primary_10_1016_j_neulet_2017_05_040 crossref_primary_10_1016_j_it_2018_10_002 crossref_primary_10_3389_fimmu_2021_665629 crossref_primary_10_1111_imr_13369 crossref_primary_10_3389_fimmu_2018_02169 crossref_primary_10_3892_etm_2018_5991 crossref_primary_10_1002_eji_201242594 crossref_primary_10_1111_imr_12031 crossref_primary_10_1242_jcs_241828 crossref_primary_10_4049_jimmunol_1102885 crossref_primary_10_1038_nri3814 crossref_primary_10_1016_j_clim_2021_108844 crossref_primary_10_1016_j_coi_2015_03_007 crossref_primary_10_1016_j_immuni_2012_06_015 crossref_primary_10_1038_ni_2890 crossref_primary_10_1111_imr_12396 crossref_primary_10_4049_immunohorizons_2000103 crossref_primary_10_1016_j_it_2021_06_003 crossref_primary_10_1016_j_molmed_2014_03_001 crossref_primary_10_1038_nrrheum_2012_58 crossref_primary_10_1002_eji_201343716 crossref_primary_10_1016_j_autrev_2022_103098 crossref_primary_10_1016_j_celrep_2020_01_009 crossref_primary_10_1038_ni_2552 crossref_primary_10_1172_jci_insight_134508 crossref_primary_10_1038_ncomms4495 crossref_primary_10_1016_j_imlet_2022_02_008 crossref_primary_10_1084_jem_20120994 crossref_primary_10_3389_fimmu_2018_01941 crossref_primary_10_1111_imr_12663 crossref_primary_10_1084_jem_20111504 crossref_primary_10_1016_j_coi_2013_05_003 crossref_primary_10_1007_s00018_013_1420_3 crossref_primary_10_1016_j_coi_2014_02_010 crossref_primary_10_1111_j_1600_065X_2012_01119_x crossref_primary_10_1038_ni_2543 crossref_primary_10_1084_jem_20211110 crossref_primary_10_1002_eji_201444825 crossref_primary_10_1089_vim_2019_0126 crossref_primary_10_4049_jimmunol_1202963 crossref_primary_10_3389_fimmu_2021_626199 crossref_primary_10_1038_s41467_021_27035_8 crossref_primary_10_1016_j_cytogfr_2014_01_001 crossref_primary_10_1111_j_1474_9726_2012_00836_x crossref_primary_10_4049_jimmunol_1401938 crossref_primary_10_1016_j_immuni_2015_12_004 crossref_primary_10_2215_CJN_09430915 crossref_primary_10_3390_v16060865 crossref_primary_10_1016_j_celrep_2018_11_070 crossref_primary_10_1111_imr_12890 crossref_primary_10_1186_s12865_022_00508_1 crossref_primary_10_1371_journal_ppat_1004096 crossref_primary_10_4049_immunohorizons_2000048 crossref_primary_10_1111_imr_70004 crossref_primary_10_1016_j_cell_2021_11_007 crossref_primary_10_1038_icb_2013_14 crossref_primary_10_1371_journal_pone_0051982 crossref_primary_10_1002_art_40670 crossref_primary_10_1016_j_immuni_2012_11_020 crossref_primary_10_1016_j_autrev_2015_04_006 crossref_primary_10_1084_jem_20161955 crossref_primary_10_4049_jimmunol_1401225 crossref_primary_10_1126_sciimmunol_aaw7636 crossref_primary_10_1111_imr_12758 crossref_primary_10_1111_j_1600_065X_2012_01124_x crossref_primary_10_1128_JVI_00983_17 crossref_primary_10_1038_s41467_018_05041_7 crossref_primary_10_4049_jimmunol_2200057 crossref_primary_10_1073_pnas_1200386109 crossref_primary_10_4049_jimmunol_1500497 crossref_primary_10_4049_jimmunol_1501463 crossref_primary_10_1038_s41467_018_05772_7 crossref_primary_10_1111_imr_12640 crossref_primary_10_4049_jimmunol_1800876 crossref_primary_10_3389_fimmu_2021_713697 crossref_primary_10_1038_s41467_017_01475_7 crossref_primary_10_1038_s41467_023_39299_3 crossref_primary_10_4049_jimmunol_1502550 crossref_primary_10_1016_j_immuni_2021_12_015 crossref_primary_10_3389_fimmu_2018_01162 crossref_primary_10_1016_j_imbio_2019_01_005 crossref_primary_10_1111_sji_12336 crossref_primary_10_1016_j_imlet_2016_01_009 crossref_primary_10_3389_fonc_2020_587809 crossref_primary_10_1016_j_imlet_2014_07_015 crossref_primary_10_1084_jem_20112256 crossref_primary_10_1016_j_mucimm_2023_07_004 crossref_primary_10_1146_annurev_immunol_090222_102834 crossref_primary_10_1093_qjmed_hcz162 crossref_primary_10_1111_j_1600_065X_2012_01112_x crossref_primary_10_1111_imr_12747 crossref_primary_10_4049_jimmunol_1700782 crossref_primary_10_1016_j_immuni_2024_02_018 crossref_primary_10_1111_imr_13047 crossref_primary_10_4049_jimmunol_1500247 crossref_primary_10_1038_nri3734 crossref_primary_10_1172_JCI132249 crossref_primary_10_1016_j_jaci_2022_09_018 crossref_primary_10_1172_jci_insight_94142 crossref_primary_10_1371_journal_ppat_1005287 crossref_primary_10_3389_fimmu_2021_620437 crossref_primary_10_1016_j_alit_2024_10_003 crossref_primary_10_1007_s11882_017_0714_1 crossref_primary_10_1128_mbio_01909_24 crossref_primary_10_3389_fimmu_2020_607626 crossref_primary_10_1038_s41590_020_0596_6 crossref_primary_10_1016_j_celrep_2014_07_059 crossref_primary_10_1016_j_immuni_2011_11_001 crossref_primary_10_1111_j_1600_065X_2012_01121_x crossref_primary_10_3389_fimmu_2015_00425 crossref_primary_10_1016_j_immuni_2015_03_002 crossref_primary_10_1084_jem_20171067 crossref_primary_10_3390_ijms22020658 crossref_primary_10_7554_eLife_06467 crossref_primary_10_4049_jimmunol_2300270 crossref_primary_10_1084_jem_20130505 crossref_primary_10_4049_jimmunol_1203288 crossref_primary_10_1073_pnas_1809925115 crossref_primary_10_1182_blood_2014_03_562231 crossref_primary_10_1172_JCI76861 crossref_primary_10_1093_intimm_dxv079 crossref_primary_10_1111_j_1600_065X_2012_01117_x crossref_primary_10_3389_fimmu_2017_00738 crossref_primary_10_1038_icb_2013_68 crossref_primary_10_1038_icb_2013_62 crossref_primary_10_1016_j_immuni_2021_08_017 crossref_primary_10_1007_s13238_015_0210_0 crossref_primary_10_1128_jvi_01532_24 crossref_primary_10_3389_fimmu_2023_1125503 crossref_primary_10_1016_j_immuni_2011_07_015 crossref_primary_10_1016_j_immuni_2015_11_017 crossref_primary_10_3389_fimmu_2018_00482 crossref_primary_10_1111_febs_15312 crossref_primary_10_1186_s12879_015_1156_9 crossref_primary_10_4049_jimmunol_1301284 crossref_primary_10_4049_jimmunol_1202084 crossref_primary_10_4110_in_2018_18_e34 crossref_primary_10_1371_journal_ppat_1011013 crossref_primary_10_3389_fimmu_2020_595535 crossref_primary_10_1371_journal_pone_0060139 crossref_primary_10_3390_vaccines12020136 crossref_primary_10_1111_j_1600_065X_2012_01122_x crossref_primary_10_1038_icb_2013_59 crossref_primary_10_1371_journal_pone_0101208 crossref_primary_10_3389_fimmu_2018_00714 crossref_primary_10_1016_j_imlet_2016_11_006 crossref_primary_10_1016_j_smim_2023_101797 crossref_primary_10_1002_JLB_5MR1020_057RR crossref_primary_10_4049_jimmunol_2200534 crossref_primary_10_1038_nri_2016_94 crossref_primary_10_3389_fimmu_2018_00159 crossref_primary_10_3389_fimmu_2018_01127 crossref_primary_10_7554_eLife_19552 crossref_primary_10_1084_jem_20141432 crossref_primary_10_1093_intimm_dxv071 crossref_primary_10_7554_eLife_17936 crossref_primary_10_1016_j_jaci_2022_08_023 crossref_primary_10_7554_eLife_04851 crossref_primary_10_1016_j_antiviral_2016_05_021 crossref_primary_10_1073_pnas_2100576118 crossref_primary_10_1038_ncomms6862 crossref_primary_10_1016_j_jneuroim_2017_08_005 crossref_primary_10_1016_j_vetimm_2013_05_006 crossref_primary_10_1002_eji_202149324 crossref_primary_10_1016_j_cellin_2023_100078 crossref_primary_10_1097_DAD_0000000000002017 crossref_primary_10_1016_j_jaut_2016_09_005 crossref_primary_10_3389_fimmu_2024_1481243 crossref_primary_10_1002_path_4141 crossref_primary_10_1002_adtp_202100235 crossref_primary_10_1128_JVI_01503_14 crossref_primary_10_4049_jimmunol_1402527 crossref_primary_10_7554_eLife_83330 crossref_primary_10_1111_sji_12942 crossref_primary_10_1016_j_ebiom_2017_08_030 crossref_primary_10_3892_mmr_2017_6132 crossref_primary_10_1182_blood_2012_11_467670 crossref_primary_10_1016_j_immuni_2014_02_005 crossref_primary_10_1016_j_isci_2023_106753 crossref_primary_10_1111_imr_12938 crossref_primary_10_3390_antib5010005 crossref_primary_10_1016_j_it_2015_05_005 crossref_primary_10_1002_eji_202149216 crossref_primary_10_1016_j_jaut_2023_103028 crossref_primary_10_1080_15321819_2014_1001031 crossref_primary_10_3389_fimmu_2020_00841 crossref_primary_10_3389_fimmu_2022_813203 crossref_primary_10_1126_sciimmunol_aam9169 crossref_primary_10_1016_j_expneurol_2014_01_024 crossref_primary_10_1155_2024_2020514 crossref_primary_10_3389_fimmu_2022_873586 crossref_primary_10_1038_ni_2166 crossref_primary_10_4049_jimmunol_2300354 crossref_primary_10_1126_science_1241146 crossref_primary_10_3389_fimmu_2017_00489 crossref_primary_10_1016_j_immuni_2012_02_002 crossref_primary_10_1111_imr_12380 crossref_primary_10_1631_jzus_B2200174 crossref_primary_10_1182_blood_2020005083 crossref_primary_10_1007_s12185_016_2035_x crossref_primary_10_1016_j_immuni_2011_06_007 crossref_primary_10_4049_jimmunol_1302617 crossref_primary_10_1155_2021_9621738 crossref_primary_10_3389_fimmu_2021_635748 crossref_primary_10_3389_fimmu_2018_02988 crossref_primary_10_1099_jgv_0_001269 crossref_primary_10_3389_fonc_2023_1105651 crossref_primary_10_1371_journal_pone_0066134 crossref_primary_10_1016_j_jhep_2023_12_032 crossref_primary_10_1111_imm_12639 crossref_primary_10_1016_j_intimp_2025_114193 crossref_primary_10_1084_jem_20171940 crossref_primary_10_1002_jgm_3694 crossref_primary_10_3389_fimmu_2017_00135 crossref_primary_10_1016_j_anndiagpath_2019_151421 crossref_primary_10_1371_journal_ppat_1008292 crossref_primary_10_15825_1995_1191_2017_2_139_151 crossref_primary_10_3389_fimmu_2017_00013 crossref_primary_10_3389_fimmu_2017_00376 crossref_primary_10_1016_j_it_2013_01_001 crossref_primary_10_1093_intimm_dxt001 crossref_primary_10_1146_annurev_immunol_041015_055605 crossref_primary_10_1038_cmi_2012_18 crossref_primary_10_4049_immunohorizons_1800069 crossref_primary_10_1111_j_1600_065X_2012_01120_x crossref_primary_10_3389_fimmu_2020_01597 crossref_primary_10_1016_j_it_2013_01_007 crossref_primary_10_1002_ctd2_24 crossref_primary_10_1126_science_1257861 crossref_primary_10_1016_j_coi_2018_02_001 crossref_primary_10_1016_j_immuni_2013_09_007 crossref_primary_10_1016_j_celrep_2020_108504 crossref_primary_10_1016_j_coi_2011_10_007 crossref_primary_10_1016_j_str_2021_10_010 crossref_primary_10_3389_fimmu_2017_01790 crossref_primary_10_4049_jimmunol_1800235 crossref_primary_10_1189_jlb_1HI1114_565R crossref_primary_10_1128_JVI_01687_18 crossref_primary_10_3389_fimmu_2018_02412 crossref_primary_10_3390_antib2040554 crossref_primary_10_1111_j_1365_2567_2011_03487_x crossref_primary_10_4049_jimmunol_1101006 crossref_primary_10_1126_scitranslmed_3008146 crossref_primary_10_1016_j_immuni_2018_08_012 crossref_primary_10_1016_j_dci_2021_104021 crossref_primary_10_3899_jrheum_130125 crossref_primary_10_1002_eji_202048745 crossref_primary_10_3389_fimmu_2022_932388 crossref_primary_10_1016_j_molimm_2014_01_008 crossref_primary_10_1128_JVI_06904_11 crossref_primary_10_3389_fneur_2020_591894 crossref_primary_10_4062_biomolther_2022_103 crossref_primary_10_1002_cyto_a_24720 crossref_primary_10_3390_ijms222413560 crossref_primary_10_4049_jimmunol_1500767 crossref_primary_10_1038_icb_2015_29 crossref_primary_10_4049_jimmunol_1700267 crossref_primary_10_1038_s41577_018_0088_1 crossref_primary_10_1111_j_1600_065X_2012_01116_x crossref_primary_10_1155_2016_5767106 crossref_primary_10_1016_j_ijpara_2016_09_004 crossref_primary_10_3389_fimmu_2021_659151 crossref_primary_10_1016_j_celrep_2015_05_042 crossref_primary_10_1073_pnas_1323985111 crossref_primary_10_1016_j_immuni_2021_08_003 crossref_primary_10_1084_jem_20180871 crossref_primary_10_1038_s41590_022_01253_8 crossref_primary_10_1158_1078_0432_CCR_21_0697 crossref_primary_10_1016_j_ebiom_2020_103197 |
| Cites_doi | 10.1016/j.immuni.2010.07.015 10.1146/annurev.immunol.26.021607.090344 10.1371/journal.pbio.0030150 10.1146/annurev.immunol.23.021704.115732 10.1016/j.immuni.2007.07.009 10.1038/nature07345 10.1016/j.immuni.2009.01.011 10.1016/j.coi.2009.09.013 10.1038/ni.1837 10.4049/jimmunol.0904023 10.1038/cmi.2010.24 10.1126/science.1176676 10.1038/nri2454 10.1126/science.281.5373.96 10.1038/ni.1715 10.1002/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O 10.1084/jem.190.8.1123 10.1093/intimm/5.6.647 10.1016/j.immuni.2009.06.016 10.4049/jimmunol.179.8.5099 10.4049/jimmunol.0903505 10.1126/science.1175870 10.4049/jimmunol.175.4.2340 10.1093/intimm/dxq047 10.1016/j.immuni.2009.07.002 10.1038/35036600 10.1111/j.1600-065X.2010.00937.x 10.1038/nature08226 10.1126/science.276.5312.589 10.4049/jimmunol.1001155 10.1016/j.immuni.2008.05.009 10.1007/s00281-010-0214-z 10.1038/nature02238 |
| ContentType | Journal Article |
| Copyright | 2011 Elsevier Inc. Copyright © 2011 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2011 Elsevier Inc. – notice: Copyright © 2011 Elsevier Inc. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7T5 H94 |
| DOI | 10.1016/j.immuni.2011.03.024 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Immunology Abstracts AIDS and Cancer Research Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AIDS and Cancer Research Abstracts Immunology Abstracts |
| DatabaseTitleList | MEDLINE - Academic AIDS and Cancer Research Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1097-4180 |
| EndPage | 960 |
| ExternalDocumentID | 21636295 10_1016_j_immuni_2011_03_024 S1074761311001944 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIAMS NIH HHS grantid: P30 AR053495 – fundername: NIAID NIH HHS grantid: R01AI080850 – fundername: NIAID NIH HHS grantid: R01 AI080850 – fundername: CIHR – fundername: NIAMS NIH HHS grantid: P30AR053495 |
| GroupedDBID | --- --K -DZ .55 .GJ 0R~ 1RT 1~5 29I 2WC 3V. 4.4 457 4G. 53G 5GY 5VS 62- 6I. 7-5 7RV 7X7 8C1 8FE 8FH AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKRW AALRI AAQFI AAQXK AAUCE AAVLU AAXJY AAXUO ABMAC ABMWF ABOCM ABVKL ACGFO ACGFS ACIWK ACPRK ADBBV ADEZE ADFRT ADJPV ADMUD AEFWE AENEX AEXQZ AFKRA AFRAH AFTJW AGGSO AGHFR AGKMS AHHHB AHMBA AHPSJ AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL BBNVY BENPR BHPHI BKEYQ BPHCQ BVXVI C45 CS3 DIK DU5 E3Z EBS EJD F5P FCP FDB FEDTE FGOYB FIRID G-2 HCIFZ HVGLF HZ~ IH2 IHE IXB J1W JIG LK8 LX5 M2O M3Z M41 M7P N9A NCXOZ O-L O9- OHT OK1 OVD OZT P2P PQQKQ PROAC R2- RCE RIG ROL RPZ SCP SES SSZ TEORI TR2 UHS WQ6 X7M Y6R ZA5 ZGI AAMRU AAYWO AAYXX ABDGV ABJNI ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEUPX AFPUW AGCQF AGQPQ AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION CGR CUY CVF ECM EFKBS EIF NPM 7X8 7T5 H94 |
| ID | FETCH-LOGICAL-c439t-8f8bbe90876f27d9d74a4893c0c9a538385fe410de8b05c0d810f086f052f7e33 |
| IEDL.DBID | IXB |
| ISSN | 1074-7613 1097-4180 |
| IngestDate | Fri Jul 11 01:59:11 EDT 2025 Fri Jul 11 05:19:28 EDT 2025 Mon Jul 21 06:06:49 EDT 2025 Fri Jul 04 04:46:09 EDT 2025 Thu Apr 24 22:57:51 EDT 2025 Fri Feb 23 02:28:42 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 Copyright © 2011 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c439t-8f8bbe90876f27d9d74a4893c0c9a538385fe410de8b05c0d810f086f052f7e33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S1074761311001944 |
| PMID | 21636295 |
| PQID | 874018494 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | proquest_miscellaneous_920804209 proquest_miscellaneous_874018494 pubmed_primary_21636295 crossref_citationtrail_10_1016_j_immuni_2011_03_024 crossref_primary_10_1016_j_immuni_2011_03_024 elsevier_sciencedirect_doi_10_1016_j_immuni_2011_03_024 |
| PublicationCentury | 2000 |
| PublicationDate | 2011-06-24 |
| PublicationDateYYYYMMDD | 2011-06-24 |
| PublicationDate_xml | – month: 06 year: 2011 text: 2011-06-24 day: 24 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Immunity (Cambridge, Mass.) |
| PublicationTitleAlternate | Immunity |
| PublicationYear | 2011 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Batista, Harwood (bib4) 2009; 9 Deenick, Chan, Ma, Gatto, Schwartzberg, Brink, Tangye (bib8) 2010; 33 Reinhardt, Liang, Locksley (bib29) 2009; 10 Mempel, Henrickson, Von Andrian (bib19) 2004; 427 Nurieva, Chung, Hwang, Yang, Kang, Ma, Wang, Watowich, Jetten, Tian, Dong (bib21) 2008; 29 Yusuf, Kageyama, Monticelli, Johnston, Ditoro, Hansen, Barnett, Crotty (bib33) 2010; 185 Chen, Trounstine, Alt, Young, Kurahara, Loring, Huszar (bib5) 1993; 5 Pereira, Kelly, Xu, Cyster (bib25) 2009; 460 Vinuesa, Linterman, Goodnow, Randall (bib30) 2010; 237 Coffey, Alabyev, Manser (bib6) 2009; 30 Johnston, Poholek, DiToro, Yusuf, Eto, Barnett, Dent, Craft, Crotty (bib15) 2009; 325 Nurieva, Chung, Martinez, Yang, Tanaka, Matskevitch, Wang, Dong (bib22) 2009; 325 Allen, Okada, Cyster (bib2) 2007; 27 King, Tangye, Mackay (bib16) 2008; 26 Good-Jacobson, Shlomchik (bib12) 2010; 185 Haynes, Allen, Lesley, Ansel, Killeen, Cyster (bib14) 2007; 179 Qi, Cannons, Klauschen, Schwartzberg, Germain (bib28) 2008; 455 Akiba, Takeda, Kojima, Usui, Harada, Yamazaki, Ma, Tezuka, Yagita, Okumura (bib1) 2005; 175 Gatto, Paus, Basten, Mackay, Brink (bib11) 2009; 31 Hauser, Kerfoot, Haberman (bib13) 2010; 32 Okada, Miller, Parker, Krummel, Neighbors, Hartley, O'Garra, Cahalan, Cyster (bib23) 2005; 3 Nurieva, Chung (bib20) 2010; 7 Oxenius, Bachmann, Zinkernagel, Hengartner (bib24) 1998; 28 Yu, Rao, Tsai, Lee, He, Sutcliffe, Srivastava, Linterman, Zheng, Simpson (bib32) 2009; 31 Yu, Batten, Mackay, King (bib31) 2009; 21 Garside, Ingulli, Merica, Johnson, Noelle, Jenkins (bib10) 1998; 281 Poholek, Hansen, Hernandez, Eto, Chandele, Weinstein, Dong, Odegard, Kaech, Dent (bib27) 2010; 185 Ansel, McHeyzer-Williams, Ngo, McHeyzer-Williams, Cyster (bib3) 1999; 190 Crotty, Johnston, Schoenberger (bib7) 2010; 11 McHeyzer-Williams, McHeyzer-Williams (bib18) 2005; 23 Pereira, Kelly, Cyster (bib26) 2010; 22 Dent, Shaffer, Yu, Allman, Staudt (bib9) 1997; 276 Maruyama, Lam, Rajewsky (bib17) 2000; 407 Mempel (10.1016/j.immuni.2011.03.024_bib19) 2004; 427 Dent (10.1016/j.immuni.2011.03.024_bib9) 1997; 276 Nurieva (10.1016/j.immuni.2011.03.024_bib20) 2010; 7 Gatto (10.1016/j.immuni.2011.03.024_bib11) 2009; 31 Yu (10.1016/j.immuni.2011.03.024_bib31) 2009; 21 Yu (10.1016/j.immuni.2011.03.024_bib32) 2009; 31 Hauser (10.1016/j.immuni.2011.03.024_bib13) 2010; 32 Pereira (10.1016/j.immuni.2011.03.024_bib26) 2010; 22 Poholek (10.1016/j.immuni.2011.03.024_bib27) 2010; 185 Good-Jacobson (10.1016/j.immuni.2011.03.024_bib12) 2010; 185 Chen (10.1016/j.immuni.2011.03.024_bib5) 1993; 5 Garside (10.1016/j.immuni.2011.03.024_bib10) 1998; 281 Maruyama (10.1016/j.immuni.2011.03.024_bib17) 2000; 407 Reinhardt (10.1016/j.immuni.2011.03.024_bib29) 2009; 10 Nurieva (10.1016/j.immuni.2011.03.024_bib21) 2008; 29 Ansel (10.1016/j.immuni.2011.03.024_bib3) 1999; 190 Batista (10.1016/j.immuni.2011.03.024_bib4) 2009; 9 Pereira (10.1016/j.immuni.2011.03.024_bib25) 2009; 460 Haynes (10.1016/j.immuni.2011.03.024_bib14) 2007; 179 King (10.1016/j.immuni.2011.03.024_bib16) 2008; 26 Crotty (10.1016/j.immuni.2011.03.024_bib7) 2010; 11 Johnston (10.1016/j.immuni.2011.03.024_bib15) 2009; 325 Okada (10.1016/j.immuni.2011.03.024_bib23) 2005; 3 Vinuesa (10.1016/j.immuni.2011.03.024_bib30) 2010; 237 Akiba (10.1016/j.immuni.2011.03.024_bib1) 2005; 175 Qi (10.1016/j.immuni.2011.03.024_bib28) 2008; 455 Yusuf (10.1016/j.immuni.2011.03.024_bib33) 2010; 185 Deenick (10.1016/j.immuni.2011.03.024_bib8) 2010; 33 Allen (10.1016/j.immuni.2011.03.024_bib2) 2007; 27 Coffey (10.1016/j.immuni.2011.03.024_bib6) 2009; 30 McHeyzer-Williams (10.1016/j.immuni.2011.03.024_bib18) 2005; 23 Oxenius (10.1016/j.immuni.2011.03.024_bib24) 1998; 28 Nurieva (10.1016/j.immuni.2011.03.024_bib22) 2009; 325 21703537 - Immunity. 2011 Jun 24;34(6):827-9. doi: 10.1016/j.immuni.2011.06.007. |
| References_xml | – volume: 10 start-page: 385 year: 2009 end-page: 393 ident: bib29 article-title: Cytokine-secreting follicular T cells shape the antibody repertoire publication-title: Nat. Immunol. – volume: 11 start-page: 114 year: 2010 end-page: 120 ident: bib7 article-title: Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation publication-title: Nat. Immunol. – volume: 28 start-page: 390 year: 1998 end-page: 400 ident: bib24 article-title: Virus-specific MHC-class II-restricted TCR-transgenic mice: Effects on humoral and cellular immune responses after viral infection publication-title: Eur. J. Immunol. – volume: 31 start-page: 259 year: 2009 end-page: 269 ident: bib11 article-title: Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses publication-title: Immunity – volume: 190 start-page: 1123 year: 1999 end-page: 1134 ident: bib3 article-title: In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines publication-title: J. Exp. Med. – volume: 175 start-page: 2340 year: 2005 end-page: 2348 ident: bib1 article-title: The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo publication-title: J. Immunol. – volume: 281 start-page: 96 year: 1998 end-page: 99 ident: bib10 article-title: Visualization of specific B and T lymphocyte interactions in the lymph node publication-title: Science – volume: 455 start-page: 764 year: 2008 end-page: 769 ident: bib28 article-title: SAP-controlled T-B cell interactions underlie germinal centre formation publication-title: Nature – volume: 185 start-page: 313 year: 2010 end-page: 326 ident: bib27 article-title: In vivo regulation of Bcl6 and T follicular helper cell development publication-title: J. Immunol. – volume: 27 start-page: 190 year: 2007 end-page: 202 ident: bib2 article-title: Germinal-center organization and cellular dynamics publication-title: Immunity – volume: 427 start-page: 154 year: 2004 end-page: 159 ident: bib19 article-title: T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases publication-title: Nature – volume: 3 start-page: e150 year: 2005 ident: bib23 article-title: Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells publication-title: PLoS Biol. – volume: 7 start-page: 190 year: 2010 end-page: 197 ident: bib20 article-title: Understanding the development and function of T follicular helper cells publication-title: Cell. Mol. Immunol. – volume: 460 start-page: 1122 year: 2009 end-page: 1126 ident: bib25 article-title: EBI2 mediates B cell segregation between the outer and centre follicle publication-title: Nature – volume: 23 start-page: 487 year: 2005 end-page: 513 ident: bib18 article-title: Antigen-specific memory B cell development publication-title: Annu. Rev. Immunol. – volume: 31 start-page: 457 year: 2009 end-page: 468 ident: bib32 article-title: The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment publication-title: Immunity – volume: 179 start-page: 5099 year: 2007 end-page: 5108 ident: bib14 article-title: Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation publication-title: J. Immunol. – volume: 325 start-page: 1006 year: 2009 end-page: 1010 ident: bib15 article-title: Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation publication-title: Science – volume: 21 start-page: 619 year: 2009 end-page: 625 ident: bib31 article-title: Lineage specification and heterogeneity of T follicular helper cells publication-title: Curr. Opin. Immunol. – volume: 5 start-page: 647 year: 1993 end-page: 656 ident: bib5 article-title: Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus publication-title: Int. Immunol. – volume: 276 start-page: 589 year: 1997 end-page: 592 ident: bib9 article-title: Control of inflammation, cytokine expression, and germinal center formation by BCL-6 publication-title: Science – volume: 325 start-page: 1001 year: 2009 end-page: 1005 ident: bib22 article-title: Bcl6 mediates the development of T follicular helper cells publication-title: Science – volume: 407 start-page: 636 year: 2000 end-page: 642 ident: bib17 article-title: Memory B-cell persistence is independent of persisting immunizing antigen publication-title: Nature – volume: 33 start-page: 241 year: 2010 end-page: 253 ident: bib8 article-title: Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling publication-title: Immunity – volume: 185 start-page: 3117 year: 2010 end-page: 3125 ident: bib12 article-title: Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: The influence of germinal center interactions and dynamics publication-title: J. Immunol. – volume: 22 start-page: 413 year: 2010 end-page: 419 ident: bib26 article-title: Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses publication-title: Int. Immunol. – volume: 32 start-page: 239 year: 2010 end-page: 255 ident: bib13 article-title: Cellular choreography in the germinal center: New visions from in vivo imaging publication-title: Semin. Immunopathol. – volume: 26 start-page: 741 year: 2008 end-page: 766 ident: bib16 article-title: T follicular helper (TFH) cells in normal and dysregulated immune responses publication-title: Annu. Rev. Immunol. – volume: 237 start-page: 72 year: 2010 end-page: 89 ident: bib30 article-title: T cells and follicular dendritic cells in germinal center B-cell formation and selection publication-title: Immunol. Rev. – volume: 9 start-page: 15 year: 2009 end-page: 27 ident: bib4 article-title: The who, how and where of antigen presentation to B cells publication-title: Nat. Rev. Immunol. – volume: 185 start-page: 190 year: 2010 end-page: 202 ident: bib33 article-title: Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150) publication-title: J. Immunol. – volume: 30 start-page: 599 year: 2009 end-page: 609 ident: bib6 article-title: Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles publication-title: Immunity – volume: 29 start-page: 138 year: 2008 end-page: 149 ident: bib21 article-title: Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages publication-title: Immunity – volume: 33 start-page: 241 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib8 article-title: Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling publication-title: Immunity doi: 10.1016/j.immuni.2010.07.015 – volume: 26 start-page: 741 year: 2008 ident: 10.1016/j.immuni.2011.03.024_bib16 article-title: T follicular helper (TFH) cells in normal and dysregulated immune responses publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.26.021607.090344 – volume: 3 start-page: e150 year: 2005 ident: 10.1016/j.immuni.2011.03.024_bib23 article-title: Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0030150 – volume: 23 start-page: 487 year: 2005 ident: 10.1016/j.immuni.2011.03.024_bib18 article-title: Antigen-specific memory B cell development publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.23.021704.115732 – volume: 27 start-page: 190 year: 2007 ident: 10.1016/j.immuni.2011.03.024_bib2 article-title: Germinal-center organization and cellular dynamics publication-title: Immunity doi: 10.1016/j.immuni.2007.07.009 – volume: 455 start-page: 764 year: 2008 ident: 10.1016/j.immuni.2011.03.024_bib28 article-title: SAP-controlled T-B cell interactions underlie germinal centre formation publication-title: Nature doi: 10.1038/nature07345 – volume: 30 start-page: 599 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib6 article-title: Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles publication-title: Immunity doi: 10.1016/j.immuni.2009.01.011 – volume: 21 start-page: 619 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib31 article-title: Lineage specification and heterogeneity of T follicular helper cells publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2009.09.013 – volume: 11 start-page: 114 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib7 article-title: Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation publication-title: Nat. Immunol. doi: 10.1038/ni.1837 – volume: 185 start-page: 313 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib27 article-title: In vivo regulation of Bcl6 and T follicular helper cell development publication-title: J. Immunol. doi: 10.4049/jimmunol.0904023 – volume: 7 start-page: 190 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib20 article-title: Understanding the development and function of T follicular helper cells publication-title: Cell. Mol. Immunol. doi: 10.1038/cmi.2010.24 – volume: 325 start-page: 1001 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib22 article-title: Bcl6 mediates the development of T follicular helper cells publication-title: Science doi: 10.1126/science.1176676 – volume: 9 start-page: 15 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib4 article-title: The who, how and where of antigen presentation to B cells publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2454 – volume: 281 start-page: 96 year: 1998 ident: 10.1016/j.immuni.2011.03.024_bib10 article-title: Visualization of specific B and T lymphocyte interactions in the lymph node publication-title: Science doi: 10.1126/science.281.5373.96 – volume: 10 start-page: 385 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib29 article-title: Cytokine-secreting follicular T cells shape the antibody repertoire publication-title: Nat. Immunol. doi: 10.1038/ni.1715 – volume: 28 start-page: 390 year: 1998 ident: 10.1016/j.immuni.2011.03.024_bib24 article-title: Virus-specific MHC-class II-restricted TCR-transgenic mice: Effects on humoral and cellular immune responses after viral infection publication-title: Eur. J. Immunol. doi: 10.1002/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O – volume: 190 start-page: 1123 year: 1999 ident: 10.1016/j.immuni.2011.03.024_bib3 article-title: In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines publication-title: J. Exp. Med. doi: 10.1084/jem.190.8.1123 – volume: 5 start-page: 647 year: 1993 ident: 10.1016/j.immuni.2011.03.024_bib5 article-title: Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus publication-title: Int. Immunol. doi: 10.1093/intimm/5.6.647 – volume: 31 start-page: 259 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib11 article-title: Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses publication-title: Immunity doi: 10.1016/j.immuni.2009.06.016 – volume: 179 start-page: 5099 year: 2007 ident: 10.1016/j.immuni.2011.03.024_bib14 article-title: Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation publication-title: J. Immunol. doi: 10.4049/jimmunol.179.8.5099 – volume: 185 start-page: 190 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib33 article-title: Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150) publication-title: J. Immunol. doi: 10.4049/jimmunol.0903505 – volume: 325 start-page: 1006 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib15 article-title: Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation publication-title: Science doi: 10.1126/science.1175870 – volume: 175 start-page: 2340 year: 2005 ident: 10.1016/j.immuni.2011.03.024_bib1 article-title: The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo publication-title: J. Immunol. doi: 10.4049/jimmunol.175.4.2340 – volume: 22 start-page: 413 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib26 article-title: Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses publication-title: Int. Immunol. doi: 10.1093/intimm/dxq047 – volume: 31 start-page: 457 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib32 article-title: The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment publication-title: Immunity doi: 10.1016/j.immuni.2009.07.002 – volume: 407 start-page: 636 year: 2000 ident: 10.1016/j.immuni.2011.03.024_bib17 article-title: Memory B-cell persistence is independent of persisting immunizing antigen publication-title: Nature doi: 10.1038/35036600 – volume: 237 start-page: 72 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib30 article-title: T cells and follicular dendritic cells in germinal center B-cell formation and selection publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2010.00937.x – volume: 460 start-page: 1122 year: 2009 ident: 10.1016/j.immuni.2011.03.024_bib25 article-title: EBI2 mediates B cell segregation between the outer and centre follicle publication-title: Nature doi: 10.1038/nature08226 – volume: 276 start-page: 589 year: 1997 ident: 10.1016/j.immuni.2011.03.024_bib9 article-title: Control of inflammation, cytokine expression, and germinal center formation by BCL-6 publication-title: Science doi: 10.1126/science.276.5312.589 – volume: 185 start-page: 3117 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib12 article-title: Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: The influence of germinal center interactions and dynamics publication-title: J. Immunol. doi: 10.4049/jimmunol.1001155 – volume: 29 start-page: 138 year: 2008 ident: 10.1016/j.immuni.2011.03.024_bib21 article-title: Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages publication-title: Immunity doi: 10.1016/j.immuni.2008.05.009 – volume: 32 start-page: 239 year: 2010 ident: 10.1016/j.immuni.2011.03.024_bib13 article-title: Cellular choreography in the germinal center: New visions from in vivo imaging publication-title: Semin. Immunopathol. doi: 10.1007/s00281-010-0214-z – volume: 427 start-page: 154 year: 2004 ident: 10.1016/j.immuni.2011.03.024_bib19 article-title: T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases publication-title: Nature doi: 10.1038/nature02238 – reference: 21703537 - Immunity. 2011 Jun 24;34(6):827-9. doi: 10.1016/j.immuni.2011.06.007. |
| SSID | ssj0014590 |
| Score | 2.5362911 |
| Snippet | We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 947 |
| SubjectTerms | Animals Antigens - immunology B-Lymphocytes - cytology B-Lymphocytes - immunology Cell Differentiation Cell Movement Germinal Center - cytology Germinal Center - immunology Mice Phenotype T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology |
| Title | Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone |
| URI | https://dx.doi.org/10.1016/j.immuni.2011.03.024 https://www.ncbi.nlm.nih.gov/pubmed/21636295 https://www.proquest.com/docview/874018494 https://www.proquest.com/docview/920804209 |
| Volume | 34 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwED4hEIgF8aa85IE11HXsxB5bRHkJBh6iYrFix5GKqrSCMvDvOTtJgQGQ2KLYjiyfcw_7u-8AjqS1JhUqiXjqFAYoqYiMzwKx1DmWUkuV8fnO1zfJ-QO_HIjBHJw0uTAeVlnr_kqnB21dv2nXq9meDIftOw8lxCA89qRnGIp7TtCYy5DEN-jNbhK4UHSGO8TeTfpcwHgNQw5GTeQZH1PGfzJPP7mfwQz1V2Gl9h9Jt5riGsy5ch0Wq4qS7-uwdF3flW-AO6twLiPiT3DdC-nhw2hEsjIn96TvybgDBpWg5Zlgc2j8giEiFx5X5F1RMiwJ-okknB4WnwOfxqXbhIf-6f3JeVQXVYgs-h7TSBbSGKc8E13B0lzlKc88AY2lVmWo_WIpCsc7NHfSUGFpLju0wLinoIIVqYvjLZgv8fM7QAQGuKaTKGtkzjnLMwyzucOIzbGMuqxoQdyspbY147gvfDHSDbTsWVcS0F4CmsYaJdCCaDZqUjFu_NE_bcSkv-0cjUbhj5GkkarGn8rflGSlG7-96lCnUHL1SxfF0NfmjKoWbFcbYjZbhj5uwpTY_ffM9mC5OrtOIsb3YX768uYO0PmZmkNY6F7dPl4dhl3-Ac4_Alg |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwEB7x0AIXxPIsr_WBa7auY8fxERClZSkXilTtxYodRyqq0grKgX_P2EnKcmCRuEWxHVkeZ-Yb-5sZgLPUWiOFSiIunUIHRYrI-CgQS51jklqqjI93HtwlvQd-MxKjJbhsYmE8rbLW_ZVOD9q6ftOuV7M9G4_b955KiE547JOeoSvOl2EV0YD09Rv6o4vFVQIXii6Ih9i9iZ8LJK9xCMKoM3nGvynjn9mnz_BnsEPdLdisASQ5r-b4E5ZcuQ0_qpKSr9uwNqgvy3fAXVdElwnxR7juiVzgw2RCsjInQ9L12bgDCZWg6Zlhc2j8h0RE-p5Y5LEoGZcEgSIJx4fF-8C_09LtwkP3anjZi-qqCpFF8DGP0iI1ximfiq5gMle55JnPQGOpVRmqvzgVheMdmrvUUGFpnnZogY5PQQUrpIvjPVgp8fMHQAR6uKaTKGvSnHOWZ-hnc4cum2MZdVnRgrhZS23rlOO-8sVEN9yyR11JQHsJaBprlEALosWoWZVy44v-shGT_rB1NFqFL0aSRqoa_yp_VZKVbvryrEOhwpSr_3RRDME2Z1S1YL_aEIvZMgS5CVPi8Nsz-wXrveHgVt_27_4cwUZ1kJ1EjB_DyvzpxZ0gEpqb07DT3wCqOAPU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Germinal+Center+B+Cell+and+T+Follicular+Helper+Cell+Development+Initiates+in+the+Interfollicular+Zone&rft.jtitle=Immunity+%28Cambridge%2C+Mass.%29&rft.au=Kerfoot%2C+Steven%C2%A0M.&rft.au=Yaari%2C+Gur&rft.au=Patel%2C+Jaymin%C2%A0R.&rft.au=Johnson%2C+Kody%C2%A0L.&rft.date=2011-06-24&rft.pub=Elsevier+Inc&rft.issn=1074-7613&rft.eissn=1097-4180&rft.volume=34&rft.issue=6&rft.spage=947&rft.epage=960&rft_id=info:doi/10.1016%2Fj.immuni.2011.03.024&rft.externalDocID=S1074761311001944 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1074-7613&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1074-7613&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1074-7613&client=summon |