Comprehensive analysis of TP53 and SPOP mutations and their impact on survival in metastatic prostate cancer

• Published in: Frontiers in oncology Vol. 12; p. 957404
• Main Authors: Zhou, Jie, Lai, Yiming, Peng, Shengmeng, Tang, Chen, Chen, Yongming, Li, Lingfeng, Huang, Hai, Guo, Zhenghui
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 31.08.2022
• Subjects: biomarkers; metastatic prostate cancer; mutation; Oncology; prognosis; SPOP; TP53

Although TP53 and SPOP are frequently mutated in metastatic prostate cancer (PCa), their prognostic value is ambiguous, and large sample studies are lacking, especially when they co-occur with other genetic alterations.BackgroundAlthough TP53 and SPOP are frequently mutated in metastatic prostate ca...