Effects of lysophosphatidic acid on melanogenesis
In this study, we investigated the effects of lysophosphatidic acid (LPA) on melanogenesis in Mel-Ab cells. We found that LPA significantly attenuates melanin synthesis, and reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. Interestingly, LPA was also found to induce the acti...
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| Published in | Chemistry and physics of lipids Vol. 127; no. 2; pp. 199 - 206 |
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| Language | English |
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| Abstract | In this study, we investigated the effects of lysophosphatidic acid (LPA) on melanogenesis in Mel-Ab cells. We found that LPA significantly attenuates melanin synthesis, and reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. Interestingly, LPA was also found to induce the activation of a 90
kDa ribosomal S6 kinase (RSK-1), which is known to phosphorylate microphthalmia-associated transcription factor (MITF) at serine 409. Though it has been previously reported that the phosphorylation of MITF is followed by the degradation of MITF, we found that LPA significantly inhibited MITF promoter activity, and that this reduced MITF and tyrosinase protein production. Our results indicate that LPA contributes to reduced melanin synthesis via the down-regulation of MITF. |
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| AbstractList | In this study, we investigated the effects of lysophosphatidic acid (LPA) on melanogenesis in Mel-Ab cells. We found that LPA significantly attenuates melanin synthesis, and reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. Interestingly, LPA was also found to induce the activation of a 90 kDa ribosomal S6 kinase (RSK-1), which is known to phosphorylate microphthalmia-associated transcription factor (MITF) at serine 409. Though it has been previously reported that the phosphorylation of MITF is followed by the degradation of MITF, we found that LPA significantly inhibited MITF promoter activity, and that this reduced MITF and tyrosinase protein production. Our results indicate that LPA contributes to reduced melanin synthesis via the down-regulation of MITF. In this study, we investigated the effects of lysophosphatidic acid (LPA) on melanogenesis in Mel-Ab cells. We found that LPA significantly attenuates melanin synthesis, and reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. Interestingly, LPA was also found to induce the activation of a 90 kDa ribosomal S6 kinase (RSK-1), which is known to phosphorylate microphthalmia-associated transcription factor (MITF) at serine 409. Though it has been previously reported that the phosphorylation of MITF is followed by the degradation of MITF, we found that LPA significantly inhibited MITF promoter activity, and that this reduced MITF and tyrosinase protein production. Our results indicate that LPA contributes to reduced melanin synthesis via the down-regulation of MITF. |
| Author | Park, Kyoung-Chan Kwon, Sun-Bang Kim, Dong-Seok Park, Seo-Hyoung Youn, Sang-Woong |
| Author_xml | – sequence: 1 givenname: Dong-Seok surname: Kim fullname: Kim, Dong-Seok organization: Research Division for Human Life Sciences, Seoul National University, Seoul, South Korea – sequence: 2 givenname: Seo-Hyoung surname: Park fullname: Park, Seo-Hyoung organization: Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, South Korea – sequence: 3 givenname: Sun-Bang surname: Kwon fullname: Kwon, Sun-Bang organization: Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, South Korea – sequence: 4 givenname: Sang-Woong surname: Youn fullname: Youn, Sang-Woong organization: Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, South Korea – sequence: 5 givenname: Kyoung-Chan surname: Park fullname: Park, Kyoung-Chan email: gcpark@snu.ac.kr organization: Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, South Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14726002$$D View this record in MEDLINE/PubMed |
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| Keywords | S1P RSK-1 Lysophosphatidic acid Edg GSK-3 MITF Melanogenesis LPA Tyrosinase |
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| SubjectTerms | Animals Cell Line DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation - drug effects Enzyme Activation - drug effects Lysophosphatidic acid Lysophospholipids - pharmacology Melanins - biosynthesis Melanocytes - cytology Melanocytes - drug effects Melanocytes - metabolism Melanogenesis Mice Microphthalmia-Associated Transcription Factor Monophenol Monooxygenase - antagonists & inhibitors Monophenol Monooxygenase - metabolism Phosphorylation Promoter Regions, Genetic - drug effects Ribosomal Protein S6 Kinases - drug effects Ribosomal Protein S6 Kinases - metabolism RSK-1 Serine - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Tyrosinase |
| Title | Effects of lysophosphatidic acid on melanogenesis |
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