Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects

• Published in: Nutrients Vol. 11; no. 1; p. 209
• Main Authors: Surowska, Anna, Jegatheesan, Prasanthi, Campos, Vanessa, Marques, Anne-Sophie, Egli, Léonie, Cros, Jérémy, Rosset, Robin, Lecoultre, Virgile, Kreis, Roland, Boesch, Chris, Pouymayou, Bertrand, Schneiter, Philippe, Tappy, Luc
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.01.2019; MDPI
• Subjects: analysis of variance; Beverages; calorimetry; Corn syrup; cross-over studies; Diabetes; Diet; dietary protein; Energy; energy expenditure; energy requirements; Fatty acids; Fatty liver; Females; high carbohydrate diet; high energy diet; high fat diet; Insulin resistance; Lactose; lipid content; Lipids; liver; Liver diseases; low fat diet; magnetism; men; Metabolism; Metabolites; muscles; overfeeding; protein content; Proteins; randomized clinical trials; spectroscopy; Sucrose; Triglycerides; weight control; women; Switzerland; dietary protein content; sucrose overfeeding; plasma triglyceride; dietary fat content; energy expenditure; intrahepatocellular lipids; intramyocellular lipids; hepatic steatosis

Sucrose overfeeding increases intrahepatocellular (IHCL) and intramyocellular (IMCL) lipid concentrations in healthy subjects. We hypothesized that these effects would be modulated by diet protein/fat content. Twelve healthy men and women were studied on two occasions in a randomized, cross-over tri...