The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized Controlled Trial

• Published in: Nutrients Vol. 11; no. 10; p. 2543
• Main Authors: Marin-Alejandre, Bertha Araceli, Abete, Itziar, Cantero, Irene, Monreal, J. Ignacio, Elorz, Mariana, Herrero, José Ignacio, Benito-Boillos, Alberto, Quiroga, Jorge, Martinez-Echeverria, Ana, Uriz-Otano, Juan Isidro, Huarte-Muniesa, María Pilar, Tur, Josep A., Martinez, J. Alfredo, Zulet, M. Angeles
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.10.2019; MDPI
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol; anthropometric measurements; antioxidant activity; Biomarkers; Body composition; Caloric Restriction; Carbohydrates; Clinical trials; Diabetes; Diet; Diet, Mediterranean; elasticity imaging techniques; Energy; Energy intake; Exercise; Fatty liver; Female; Humans; lipid content; liver; Liver - physiopathology; Liver diseases; low calorie diet; magnetic resonance imaging; Male; Meals; Mediterranean diet; Metabolism; Middle Aged; NMR; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - diet therapy; Non-alcoholic Fatty Liver Disease - physiopathology; Nuclear magnetic resonance; Nutrition research; Obesity; Obesity - complications; Obesity - diet therapy; Obesity - physiopathology; prediction; randomized clinical trials; regression analysis; transaminases; Ultrasonic imaging; Weight control; weight loss; Weight Loss - physiology; Spain; Obesity; NAFLD; Mediterranean Diet; AHA; fatty liver; FLiO; dietary intervention

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. NAFLD management is mainly focused on weight loss, but the optimal characteristics of the diet demand further investigation. This study aims to evaluate the effects of two personalized energy-restricted diets on the...