Phage Display Revealed the Complex Structure of the Epitope of the Monoclonal Antibody 10H10

• Published in: International journal of molecular sciences Vol. 25; no. 19; p. 10311
• Main Authors: Shanshin, Daniil V., Borisevich, Sophia S., Shaprova, Olga N., Nesmeyanova, Valentina S., Bondar, Alexander A., Porozov, Yuri B., Khamitov, Edward M., Kolosova, Evgeniia A., Shelemba, Arseniya A., Ushkalenko, Nikita D., Protopopova, Elena V., Sergeev, Artemiy A., Loktev, Valery B., Shcherbakov, Dmitriy N.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2024; MDPI
• Subjects: Amino Acid Sequence; Amino acids; Animals; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antigenic determinants; Antigens; Binding sites; Cell Surface Display Techniques; Cloning; Dengue fever; Dengue Virus - immunology; Encephalitis; Encephalitis Viruses, Tick-Borne - immunology; Energy; Epitope Mapping - methods; Epitopes - chemistry; Epitopes - immunology; Health aspects; Humans; Identification and classification; Immunology; Infections; Mice; Models, Molecular; Monoclonal antibodies; Peptide Library; Peptides; Phages; Physiological aspects; Proteins; Simulation; Structure; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - immunology; Viral infections; Viruses; West Nile virus; Zika Virus - immunology; Russia; recombinant proteins; chimeric antibody; monoclonal antibody; phage display; flavivirus

The annual number of reported human cases of flavivirus infections continues to increase. Measures taken by local healthcare systems and international organizations are not fully successful. In this regard, new approaches to treatment and prevention of flavivirus infections are relevant. One promisi...