Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease

• Published in: Nutrients Vol. 12; no. 5; p. 1260
• Main Authors: Perez-Diaz-del-Campo, Nuria, Abete, Itziar, Cantero, Irene, Marin-Alejandre, Bertha Araceli, Monreal, J. Ignacio, Elorz, Mariana, Herrero, José Ignacio, Benito-Boillos, Alberto, Riezu-Boj, Jose I., Milagro, Fermín I., Tur, Josep A., Martinez, J. Alfredo, Zulet, M. Angeles
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.04.2020; MDPI
• Subjects: Adaptor Proteins, Signal Transducing - genetics; administrative management; Alcohol; Alleles; biomarkers; blood; body composition; Carbohydrates; Cholesterol; Diabetes; Diet; Disease Progression; eating habits; Fatty liver; Fatty Liver - etiology; Fatty Liver - genetics; Female; Food; food intake; frequency; Genetic Association Studies; genetic polymorphism; Genetic Predisposition to Disease; genetic variation; genotype; genotyping; Glycemic index; Hemoglobin; Humans; image analysis; Insulin resistance; Lifestyles; liver; Liver diseases; Male; Manufacturers; Metabolic syndrome; Middle Aged; monounsaturated fatty acids; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - genetics; nutrients; Obesity; Obesity - etiology; Obesity - genetics; Pathogenesis; Polymorphism; Polymorphism, Genetic; Questionnaires; regression analysis; Risk; Severity of Illness Index; Triglycerides; ultrasonography; Weight control; Spain; NAFLD; polymorphisms; steatosis; obesity; SH2B1

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide. Some genetic variants might be involved in the progression of this disease. The study hypothesized that individuals with the rs7359397 T allele have a higher risk of developing severe stages of NAFLD compared with...