Analysis of glycated serum proteins in type 2 diabetes patients with nephropathy

• Published in: Biotechnology and bioprocess engineering Vol. 19; no. 1; pp. 83 - 92
• Main Authors: Kim, Mi-Ryung, Yu, Shin-Ae, Kim, Mi-Yeon, Choi, Kyung Mook, Kim, Chan-Wha
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2014; Springer Berlin Heidelberg; Springer Nature B.V; 한국생물공학회
• Subjects: Apolipoproteins; Biomarkers; Biomedical research; Biotechnology; Chemistry; Chemistry and Materials Science; Chronic illnesses; complement; Diabetes; Diabetic nephropathy; electrophoresis; gels; glycation; glycemic control; Glycoproteins; High density lipoprotein; Hyperglycemia; Immunoglobulins; Industrial and Production Engineering; Insulin; Kidney diseases; kidneys; Life sciences; Metabolism; noninsulin-dependent diabetes mellitus; Pathogenesis; patients; Proteins; proteome; proteomics; Research Paper; Silver; silver nitrate; Studies; 생물공학; South Korea; glycation; glycoproteome; fructosamine; biomarker; type 2 diabetic nephropathy

The aim of this study was to screen for proteins that are susceptible to glycation under hyperglycemic conditions in patients with type 2 diabetic nephropathy. Serum proteins were analyzed by a proteomic approach using two-dimensional electrophoresis (2-DE) and ESI-Q-TOF MS/MS. Gels were stained wit...