Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy

• Published in: Frontiers in oncology Vol. 12; p. 829212
• Main Authors: Guo, Rui, Liu, Tian, Shasaltaneh, Marzieh Dehghan, Wang, Xuan, Imani, Saber, Wen, QingLian
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 27.06.2022
• Subjects: adenylate cyclase; cAMP signaling; chemoresistance; molecular targeted therapy; Oncology; signaling pathway 4

The adenylate cyclase (ADCY) superfamily is a group of glycoproteins regulating intracellular signaling. ADCYs act as key regulators in the cyclic adenosine monophosphate (cAMP) signaling pathway and are related to cell sensitivity to chemotherapy and ionizing radiation. Many members of the superfam...