Hepatocyte Growth Factor Gene-modified Bone Marrow-derived Mesenchymal Stem Cells Transplantation Promotes Angiogenesis in a Rat Model of Hindlimb Ischemia

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 33; no. 4; pp. 511 - 519
• Main Authors: Su, Guan-hua, Sun, Yu-fei, Lu, Yong-xin, Shuai, Xin-xin, Liao, Yu-hua, Liu, Qi-yun, Han, Jun, Luo, Ping
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2013; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China%Department of Cardiology, Wuhan Pu'ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China
• Subjects: Animals; Bone Marrow - metabolism; Bone Marrow - pathology; Bone Marrow Transplantation; Cells, Cultured; Hepatocyte Growth Factor - genetics; Hindlimb - pathology; Medicine; Medicine & Public Health; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - pathology; Neovascularization, Physiologic - genetics; Rats; Sprague-Dawley; 基因修饰; 大鼠模型; 干细胞移植; 缺血; 肝细胞生长因子; 血管新生; 骨髓间充质干细胞; mesenchymal stem cell; gene therapy; peripheral arterial disease; angiogenesis; hepatocyte growth factor

Summary： Angiogenic gene therapy and cell-based therapy for peripheral arterial disease （PAD） have been studied intensively currently. This study aimed to investigate whether combining mesenchymal stem cells （MSCs）transplantation with ex vivo human hepatocyte growth factor （HGF） gene transfer was mo...