An International Ki67 Reproducibility Study

• Published in: JNCI : Journal of the National Cancer Institute Vol. 105; no. 24; pp. 1897 - 1906
• Main Authors: POLLEY, Mei-Yin C, LEUNG, Samuel C. Y, GOWN, Allen M, SYMMANS, W. Fraser, PIPER, Tammy, MEHL, Erika, ENOS, Rebecca A, HAYES, Daniel F, DOWSETT, Mitch, NIELSEN, Torsten O, McSHANE, Lisa M, DONGXIA GAO, HUGH, Judith C, MASTROPASQUA, Mauro G, VIALE, Giuseppe, ZABAGLO, Lila A, PENAULT-LLORCA, Frédérique, BARTLETT, John M. S
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 18.12.2013; Oxford Publishing Limited (England)
• Subjects: Biological and medical sciences; Biomarkers, Tumor - analysis; Breast cancer; Breast Neoplasms - immunology; Correlation analysis; Female; Humans; Immunohistochemistry; International Cooperation; Ki-67 Antigen - analysis; Laboratories; Laboratories - standards; Medical sciences; Observer Variation; Proteins; Reproducibility of Results; Standardization; Tissue Array Analysis - standards; Tumors; Ki67 antigen; Biological marker; Cancerology; Reproducibility; International

In breast cancer, immunohistochemical assessment of proliferation using the marker Ki67 has potential use in both research and clinical management. However, lack of consistency across laboratories has limited Ki67's value. A working group was assembled to devise a strategy to harmonize Ki67 ana...