Grey matter density and GABAA binding potential show a positive linear relationship across cortical regions

• Published in: Neuroscience Vol. 235; pp. 226 - 231
• Main Authors: Duncan, N.W., Gravel, P., Wiebking, C., Reader, A.J., Northoff, G.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 03.04.2013; Elsevier
• Subjects: Adolescent; Adult; anatomical imaging; benzodiazepine receptor; Biological and medical sciences; Brain - anatomy & histology; Brain - diagnostic imaging; brain morphometry; Cerebral Cortex - anatomy & histology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - metabolism; Female; flumazenil; Flumazenil - analogs & derivatives; Fundamental and applied biological sciences. Psychology; GABA Modulators; Humans; Image Processing, Computer-Assisted; Linear Models; Magnetic Resonance Imaging; Male; Neurology; Positron-Emission Tomography; Radiopharmaceuticals; receptor density; Receptors, GABA-A - metabolism; VBM; Vertebrates: nervous system and sense organs; Young Adult; VBM; 18F-FMZ-PET; GM; WM; benzodiazepine receptor; CSF; BPND; flumazenil; receptor density; brain morphometry; anatomical imaging; BP ND; binding potential; white matter; 18F-flumazenil PET; Voxel based morphometry; cerebrospinal fluid; grey matter; Grey matter; Central nervous system; Benzodiazepine receptor; Density; Encephalon; Flumazenil; Imaging; Morphometry; Biological receptor

► Combine GABAA receptor PET and grey-matter MRI imaging. ► Correlate BPND and VBM grey-matter densities. ► Show that regions with high GM density tend to have high GABAA BPND. ► Suggest at subject level that more variability in relationship may be present. Voxel based morphometry (VBM) is a widely...