Expression of a disintegrin and metalloproteinase-33 protein in vocal fold polyps

• Published in: Journal of laryngology and otology Vol. 129; no. 7; pp. 688 - 692
• Main Authors: Akdogan, M V, Erinanc, H, Topal, O, Erbek, S S
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.07.2015
• Subjects: ADAM Proteins - analysis; Adolescent; Adult; Aged; Alzheimer's disease; Angiogenesis; Asthma; Chi-square test; Disease; Disintegrins - analysis; Female; Humans; Immunohistochemistry; Laryngeal Diseases - metabolism; Main Articles; Male; Middle Aged; Pathogenesis; Polyps; Polyps - chemistry; Statistical analysis; Surgery; Vocal Cords; Young Adult; United States > US; California; Human; Immunohistochemistry; Airway Remodeling; Angiogenesis Inducing Agents; Laryngeal Diseases; A Disintegrin and Metalloproteinase Domain 33 Protein; Vocal Cords
• DOI: 10.1017/S0022215115000894
• ISSN: 0022-2151

This study aimed to evaluate the association of a disintegrin and metalloproteinase-33 protein ('ADAM-33') expression in vocal polyp formation and to determine its correlation with clinical characteristics. Medical charts and histological sections of 32 patients diagnosed with vocal polyps who underwent surgery were analysed. Controls were histopathologically normal vocal fold tissues obtained from 36 patients who underwent surgery for laryngeal squamous cell carcinoma. Immunohistochemical staining was performed to detect ADAM-33 expression in epithelial cells, stroma and vessels. All epithelial, stromal and vascular staining scores were significantly greater in polyp tissue than in controls (p < 0.001). Stromal ADAM-33 staining scores were higher in vocal polyp patients with a symptom duration of less than six months (p < 0.05). Vocal overuse or the presence of reflux symptoms, sinonasal symptoms or allergy did not affect ADAM-33 immunostaining scores (p = 0.05). In this study, ADAM-33 immunostaining was significantly increased in vocal polyps. Therefore, over-expression of this protein may be associated with vocal polyp pathogenesis.