Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation

• Published in: Nutrients Vol. 12; no. 10; p. 3139
• Main Authors: Vazquez-Madrigal, Carlos, Lopez, Soledad, Grao-Cruces, Elena, Millan-Linares, Maria C., Rodriguez-Martin, Noelia M., Martin, Maria E., Alba, Gonzalo, Santa-Maria, Consuelo, Bermudez, Beatriz, Montserrat-de la Paz, Sergio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.10.2020; MDPI
• Subjects: acute effects; Adult; Antigens; assays; Autoimmune diseases; B7-1 Antigen - genetics; B7-1 Antigen - metabolism; blood serum; Cell Differentiation; Cells, Cultured; Chromatography; Cytokines; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - physiology; dietary fat; Dietary Fats - administration & dosage; Dietary Fats - adverse effects; exhibitions; Fatty acids; Fatty Acids - administration & dosage; Fatty Acids - adverse effects; Female; Flow cytometry; Gene Expression; genes; Granulocyte-Macrophage Colony-Stimulating Factor - blood; homeostasis; Homeostasis - drug effects; Humans; immunity; inflammation; interleukin-10; interleukin-12; Interleukin-3 Receptor alpha Subunit - genetics; Interleukin-3 Receptor alpha Subunit - metabolism; knowledge; Lipids; lipoproteins; Lipoproteins - metabolism; macrophage colony-stimulating factor; Male; Meals; Metabolism; Milk; Monocytes; monounsaturated fatty acids; nutrients; Olive Oil; Polyunsaturated fatty acids; Postprandial Period - immunology; T-lymphocytes; Triglycerides - metabolism; Germany; Spain; dendritic cells; fatty acids; triglyceride-rich lipoprotein; chylomicron; olive oil; myeloid lineage; postprandial state

Dietary fatty acids have been demonstrated to modulate systemic inflammation and induce the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial triglyceride-rich lipoproteins (TRLs) may have acute effects on immunometabolic homeostasis by modulating dend...