Synthesis of the full-length hepatitis B virus core protein and its capsid formation

• Published in: Organic & biomolecular chemistry Vol. 22; no. 11; pp. 2218 - 2225
• Main Authors: Aoki, Keisuke, Tsuda, Shugo, Ogata, Naoko, Kataoka, Michiyo, Sasaki, Jumpei, Inuki, Shinsuke, Ohno, Hiroaki, Watashi, Koichi, Yoshiya, Taku, Oishi, Shinya
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 13.03.2024
• Subjects: Antiviral Agents - metabolism; Assembly; C-Terminus; Capsid - chemistry; Capsid Proteins - metabolism; Chemical synthesis; Chronic infection; Cirrhosis; Core protein; Hepatitis; Hepatitis B; Hepatitis B - metabolism; Hepatitis B virus; Humans; Liver cancer; Modulators; Natural products; Nucleic Acids; Proteins; Viral Core Proteins - analysis; Viral Core Proteins - chemistry; Viral Core Proteins - metabolism; Virions; Virus Replication

Chronic infection with hepatitis B virus (HBV) is a major cause of cirrhosis and liver cancer. Capsid assembly modulators can induce error-prone assembly of HBV core proteins to prevent the formation of infectious virions, representing promising candidates for treating chronic HBV infections. To exp...