Overexpression of miR-146a Might Regulate Polarization Transitions of BV-2 Cells Induced by High Glucose and Glucose Fluctuations

• Published in: Frontiers in endocrinology (Lausanne) Vol. 10; p. 719
• Main Authors: Huang, Yinqiong, Liao, Zhenling, Lin, Xiahong, Wu, Xiaohong, Chen, Xiaoyu, Bai, Xuefeng, Zhuang, Yong, Yang, Yingxia, Zhang, Jinying
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 22.10.2019
• Subjects: Endocrinology; glucose fluctuation; microglia; miR-146a; neuroinflammation; polarization transitions

Microglia are critical in neuroinflammation. M1/M2 polarization transitions of microglial phenotypes determine the states of neuroinflammation and are regulated by multiple pathways, including miRNAs and other epigenetic regulations. This study investigated the polarization transitions of microglia...