Behavioral Determinants of Cannabinoid Self-Administration in Old World Monkeys

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 42; no. 7; pp. 1522 - 1530
• Main Authors: John, William S, Martin, Thomas J, Nader, Michael A
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.06.2017
• Subjects: Animals; Cannabinoid Receptor Agonists - administration & dosage; Cannabinoids - administration & dosage; Cercopithecidae; Cocaine; Cyclohexanols - administration & dosage; Cynomolgus; Dose-Response Relationship, Drug; Dronabinol - administration & dosage; Drugs; Food; Hypotheses; Macaca fascicularis; Macaca mulatta; Male; Marijuana; Medical research; Monkeys & apes; Original; Physiology; Reaction Time - drug effects; Reaction Time - physiology; Receptors, Cannabinoid - metabolism; Reinforcement (Psychology); Reinforcement schedules; Saimiri; Self Administration; Tetrahydrocannabinol; THC; United States > US

Reinforcing effects of Δ -tetrahydrocannabinol (THC), the primary active ingredient in marijuana, as assessed with self-administration (SA), has only been established in New World primates (squirrel monkeys). The objective of this study was to investigate some experimental factors that may enhance i...