Growth-promoting function of the cGAS-STING pathway in triple-negative breast cancer cells

• Published in: Frontiers in oncology Vol. 12; p. 851795
• Main Authors: Liu, Liang-Chih, Shen, Yi-Chun, Wang, Yuan-Liang, Wu, Wan-Rong, Chang, Ling-Chu, Chen, Ya-Huey, Lee, Chuan-Chun, Wang, Shao-Chun
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 03.08.2022
• Subjects: cGAMP; cGAS; EGFR; Oncology; ssDNA; STING; triple-negative breast cancer

The cGAS-STING axis is one of the key mechanisms guarding cells from pathogen invasion in the cytoplasmic compartment. Sensing of foreign DNA in the cytosol by the cGAS-STING axis triggers a stress cascade, culminating at stimulation of the protein kinase TBK1 and subsequently activation of inflamma...