Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12–43 years

• Published in: Psychological medicine Vol. 51; no. 9; pp. 1570 - 1580
• Main Authors: Fagerlund, Birgitte, Pantelis, Christos, Jepsen, Jens Richardt Møllegaard, Raghava, Jayachandra Mitta, Rostrup, Egill, Thomas, Marie Bjerregaard, Nielsen, Mette Ødegaard, Bojesen, Kirsten, Jensen, Karsten Gjessing, Stentebjerg-Decara, Marie, Klauber, Dea Gowers, Rudå, Ditte, Ebdrup, Bjørn H., Jessen, Kasper, Sigvard, Anne, Tangmose, Karen, Jeppesen, Pia, Correll, Christoph U., Fink-Jensen, Anders, Pagsberg, Anne Katrine, Glenthøj, Birte Yding
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.07.2021
• Subjects: Adolescent; Adult; Age; Age differences; Age Factors; Age of Onset; Analysis of covariance; Antipsychotics; Case-Control Studies; Child; Child development; Cognition & reasoning; Cognition - physiology; Cognition Disorders - physiopathology; Cognitive ability; Cognitive functioning; Cognitive impairment; Executive function; Female; Health facilities; Humans; Illnesses; Intelligence; Intelligence tests; Language; Male; Maturation; Memory; Memory, Short-Term; Mental disorders; Mental health; Motor ability; Multivariate analysis; Neuropsychological Tests; Original Articles; Psychopathology; Psychotropic drugs; Schizophrenia; Schizophrenia - physiopathology; Schizophrenic Psychology; Short term memory; Socioeconomic status; Teenagers; Timing; Verbal Learning - physiology; Young Adult; Denmark; Age of illness onset; schizophrenia; cognition; neurodevelopmental

The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the im...