Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs - Hasan, Mahmud; Marzouk, Mohamed Akmal; Adhikari, Saugat; Wright, Thomas D.; Miller, Benton P.; Matossian, Margarite D.; Elliott, Steven; Wright, Maryl; Alzoubi, Madlin; Collins-Burow, Bridgette M.; Burow, Matthew E.; Holzgrabe, Ulrike; et al. (Molecular pharmacology, 2019)
Keywords: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; Biological Availability; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Cell Line, Tumor; Cell Movement - drug effects; Cell Survival - drug effects; Drug Resistance, Neoplasm - drug effects; Estrogen Receptor alpha - metabolism; Female; Gene Expression Regulation, Neoplastic - drug effects; Humans; MAP Kinase Signaling System - drug effects; MCF-7 Cells; Melatonin - administration & dosage; Melatonin - pharmacokinetics; Melatonin - pharmacology; Mice; Receptor, Melatonin, MT1 - metabolism; Tamoxifen - administration & dosage; Tamoxifen - pharmacokinetics; Tamoxifen - pharmacology; BC; PR; MT1R; MTT; C2; LLQ; C4; DMEM; NF-κB; C5; QC; PI3K; C9; FBS; TNBC; WT; HPLC; MMC; PDX; C15; MS; GPR30; ER; ESR1; TAM-d5; MEK; TamR; LC; HER2