The Relationship between Blood Lipids and Risk of Atrial Fibrillation: Univariable and Multivariable Mendelian Randomization Analysis

• Published in: Nutrients Vol. 14; no. 1; p. 181
• Main Authors: Yang, Shengyi, Pudasaini, Rupak, Zhi, Hong, Wang, Lina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.12.2021; MDPI
• Subjects: ancestry; apolipoprotein A-I; Apolipoprotein A-I - blood; apolipoprotein B; Apolipoprotein B-100 - blood; Apolipoproteins; atrial fibrillation; Atrial Fibrillation - blood; Atrial Fibrillation - epidemiology; Atrial Fibrillation - genetics; Bias; Biobanks; blood; Cardiac arrhythmia; Causality; Cholesterol; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Cohort Studies; Estimates; Genome-Wide Association Study; High density lipoprotein; high density lipoprotein cholesterol; Humans; Lipids; Lipids - blood; Lipids - genetics; low density lipoprotein cholesterol; Mendelian Randomization Analysis; meta-analysis; Polymorphism, Single Nucleotide - genetics; Prospective Studies; risk; Risk Factors; triacylglycerols; Triglycerides - blood; Variables; United Kingdom > UK; United States > US; atrial fibrillation; causal effect; Mendelian randomization; blood lipids

We performed univariable and multivariable Mendelian randomization (MR) analysis to evaluate the association between blood lipids and risk of atrial fibrillation (AF), including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), Apolipoprote...