Efavirenz concentrations in CSF exceed IC50 for wild-type HIV

• Published in: Journal of antimicrobial chemotherapy Vol. 66; no. 2; pp. 354 - 357
• Main Authors: Best, B. M., Koopmans, P. P., Letendre, S. L., Capparelli, E. V., Rossi, S. S., Clifford, D. B., Collier, A. C., Gelman, B. B., Mbeo, G., McCutchan, J. A., Simpson, D. M., Haubrich, R., Ellis, R., Grant, I., Ellis, R. J., Marcotte, T. D., Franklin, D., Alexander, T., Letendre, S., Capparelli, E., Heaton, R. K., Atkinson, J. H., Woods, S. P., Dawson, M., Wong, J. K., Fennema-Notestine, C., Taylor, M. J., Theilmann, R., Gamst, A. C., Cushman, C., Abramson, I., Vaida, F., von Jaeger, R., McArthur, J., Smith, M., Morgello, S., Simpson, D., Mintz, L., Toperoff, W., Collier, A., Marra, C., Jones, T., Gelman, B., Head, E., Clifford, D., Al-Lozi, M., Teshome, M.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2011
• Subjects: Adult; Age; Alkynes; Anti-HIV Agents - blood; Anti-HIV Agents - cerebrospinal fluid; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; antiretroviral therapy; Antiviral agents; Benzoxazines - blood; Benzoxazines - cerebrospinal fluid; Benzoxazines - therapeutic use; Biological and medical sciences; Brain; Central nervous system; Cerebrospinal fluid; Chromatography, High Pressure Liquid; Cognition; Cyclopropanes; Drugs; Efavirenz; Female; High-performance liquid chromatography; HIV Infections - cerebrospinal fluid; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - virology; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Inhibitory Concentration 50; Male; Mass spectroscopy; Medical sciences; Middle Aged; Nervous System Diseases - cerebrospinal fluid; Nervous System Diseases - drug therapy; Nervous System Diseases - virology; Neurological diseases; Original Research; Pharmacology. Drug treatments; Random Allocation; Replication; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Antiretroviral agent; Benzoxazine derivatives; RNA-directed DNA polymerase; Acetylenic compound; Non nucleoside compound; CNS; Cerebrospinal fluid; Efavirenz; Reverse transcriptase inhibitor; non-nucleoside reverse transcriptase inhibitors; Antiviral; Immunopathology; Enzyme; Transferases; Enzyme inhibitor; Retroviridae; AIDS; Pharmacology; Concentration; Wild type; Immune deficiency; Lentivirus; Infection; Virus; Allosteric inhibitor; Nucleotidyltransferases; Viral disease; Human immunodeficiency virus

HIV-associated neurocognitive disorders remain common despite use of potent antiretroviral therapy (ART). Ongoing viral replication due to poor distribution of antivirals into the CNS may increase risk for HIV-associated neurocognitive disorders. This study's objective was to determine penetrat...