Efavirenz concentrations in CSF exceed IC50 for wild-type HIV - Best, B. M.; Koopmans, P. P.; Letendre, S. L.; Capparelli, E. V.; Rossi, S. S.; Clifford, D. B.; Collier, A. C.; Gelman, B. B.; Mbeo, G.; McCutchan, J. A.; Simpson, D. M.; Haubrich, R.; et al. (Journal of antimicrobial chemotherapy, 2011)
Keywords: Adult; Age; Alkynes; Anti-HIV Agents - blood; Anti-HIV Agents - cerebrospinal fluid; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; antiretroviral therapy; Antiviral agents; Benzoxazines - blood; Benzoxazines - cerebrospinal fluid; Benzoxazines - therapeutic use; Biological and medical sciences; Brain; Central nervous system; Cerebrospinal fluid; Chromatography, High Pressure Liquid; Cognition; Cyclopropanes; Drugs; Efavirenz; Female; High-performance liquid chromatography; HIV Infections - cerebrospinal fluid; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - virology; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Inhibitory Concentration 50; Male; Mass spectroscopy; Medical sciences; Middle Aged; Nervous System Diseases - cerebrospinal fluid; Nervous System Diseases - drug therapy; Nervous System Diseases - virology; Neurological diseases; Original Research; Pharmacology. Drug treatments; Random Allocation; Replication; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Antiretroviral agent; Benzoxazine derivatives; RNA-directed DNA polymerase; Acetylenic compound; Non nucleoside compound; CNS; Cerebrospinal fluid; Efavirenz; Reverse transcriptase inhibitor; non-nucleoside reverse transcriptase inhibitors; Antiviral; Immunopathology; Enzyme; Transferases; Enzyme inhibitor; Retroviridae; AIDS; Pharmacology; Concentration; Wild type; Immune deficiency; Lentivirus; Infection; Virus; Allosteric inhibitor; Nucleotidyltransferases; Viral disease; Human immunodeficiency virus